Cannabis Clinical Trial
— COBRAOfficial title:
ERP Studies of Acute Influences of THC and CBD on Memory Encoding and Retrieval Processes: Experiment 1
This study investigates the impact of ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on recognition memory in healthy, regular cannabis users. Participants complete the same recognition memory task after self-administering one of three different strains of cannabis flower one day and while not intoxicated another day. Event-related potentials (ERPs) are measured via electroencephalogram (EEG) during the recognition memory task. Blood is collected to quantify THC and CBD exposure. Participants also complete self-report measures of medical history, sleep quality, subjective cognitive function, physical activity, psychological functioning, substance use, and acute drug effects.
Status | Recruiting |
Enrollment | 90 |
Est. completion date | December 31, 2025 |
Est. primary completion date | December 31, 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 21 Years to 40 Years |
Eligibility | Inclusion Criteria: - Must be between the ages of 21 and 40 and provide informed consent. - Must be right-handed (Laterality Quotient > 60 on Edinburgh Handedness Inventory - Short Form). - Must use cannabis at least 4 days during the month. - Must be a cannabis user for at least a year. - Must self-report not using other illicit recreational drugs (e.g., cocaine, benzodiazepines (non-prescription), opiates (non-prescription), MDMA, sedatives, or methamphetamine) in the past 30 days. - Must not test positive on a urine toxicology test for drugs of abuse. - Must not be using psychotropic medications, however anti-depressant, non-benzodiazepine anti-anxiety, and ADHD medications are ok. ADHD medication users must be willing to abstain from ADHD medication use on appointment days. - Must not be a regular tobacco user (=4 days per week; cigarette, E-cigs, or smokeless). - Must not have used caffeine or tobacco (cigarette, E-cigs, or smokeless) for 4 hours prior to appointments. - Must have a breath alcohol level of 0 to sign consent form. - Must not be actively seeking or in treatment for any substance use disorder. - Female subjects must not be or trying to become pregnant. - Must not be in treatment for psychotic disorder or bipolar disorder; or have a history with these disorders. - Must not have any physical characteristics (e.g., thick hair, head size exceeding the limit of the net, dyed hair) or experience any technical difficulties during testing that result in a poor-quality EEG recording. |
Country | Name | City | State |
---|---|---|---|
United States | Center for Innovation and Creativity | Boulder | Colorado |
Lead Sponsor | Collaborator |
---|---|
University of Colorado, Boulder | National Institute on Drug Abuse (NIDA) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Exploratory: Associations between genes related to cannabinoid metabolism, cannabis-related behavior, and neurocognitive function with ERPs and recognition memory performance | DNA samples are collected from a baseline blood sample. | baseline, intoxicated session, and not-intoxicated session (about 3 weeks) | |
Other | Exploratory: Moderation of primary effects by baseline health and psychological functioning | Baseline health and psychological function include measures of sleep quality, affective symptoms, and substance use history. | baseline, intoxicated session, and not-intoxicated session (about 3 weeks) | |
Primary | Difference in ERP amplitude | Electroencephalography is used to quantify FN400 and parietal ERP effects. | intoxicated session and not-intoxicated session | |
Primary | Difference in recognition memory performance | Accuracy and reaction time will be used to assess task performance. | intoxicated session and not-intoxicated session (about 1 week) | |
Secondary | Difference in Flanker Task performance | Accuracy and reaction time will be used to assess task performance. | intoxicated session and not-intoxicated session (about 1 week) | |
Secondary | Difference in Flanker Task ERPs | Electroencephalography is used to quantify ERN effects. | intoxicated session and not-intoxicated session (about 1 week) | |
Secondary | Change in Positive and Negative Affect Schedule (PANAS) | The PANAS is Self-report measurement of positive and negative affect. | before and after acute cannabis use (about 30 minutes) | |
Secondary | Change in Drug Effects Questionnaire (DEQ) | The DEQ is a visual analogue scale of measure of acute drug effects. | before and after acute cannabis use (about 30 minutes) | |
Secondary | Change in Addiction Research Center Inventory (ARCI-M) | The ARCI-M is a self-report measure of subjective effects of marijuana. | before and after acute cannabis use (about 30 minutes) | |
Secondary | Change in Marijuana Craving Questionnaire | The Marijuana Craving Questionnaire is a self-report measure of marijuana craving. | before and after acute cannabis use (about 30 minutes) | |
Secondary | Change in Profile of Mood States (POMS) | The POMS is a self-report measure of mood. | before and after acute cannabis use (about 30 minutes) | |
Secondary | Change in Alcohol Craving Questionnaire | The Alcohol Craving Questionnaire is a self-report measure of alcohol craving. | before and after acute cannabis use (about 30 minutes) | |
Secondary | Change in State Adapted Paranoia Checklist-Brief (SAPC-B) | The SAPC-B is a self-report measure of paranoia. | before and after acute cannabis use (about 30 minutes) | |
Secondary | Difference in circulating cannabinoids | Blood levels of THC and CBD will be quantified. | baseline, intoxicated session, and not-intoxicated session (about 3 weeks) |
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