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NCT03253926 Clinical Trial

Effect of Lorcaserin on Cannabis Withdrawal and Self-administration

Cannabis Use Clinical Trial

Official title:
Effect of Lorcaserin on Cannabis Withdrawal and Self-administration

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03253926
Other study ID # 7475
Secondary ID
Status Completed
Phase Phase 1/Phase 2
First received
Last updated
Start date September 5, 2017
Est. completion date December 31, 2021

Study information
Verified date July 2022
Source New York State Psychiatric Institute
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

In this study, the investigators are interested in testing how lorcaserin influences the effects of cannabis in a human laboratory model of cannabis use.

Description:

In order to improve treatment outcome for cannabis use disorder (CUD), the investigators have developed a laboratory model to investigate the effects of potential treatment medications on cannabis withdrawal and on the subjective and reinforcing effects of cannabis in non treatment-seeking cannabis smokers. In this study, the investigators are interested in testing how lorcaserin influences the effects of cannabis in a human laboratory model of cannabis use.

Recruitment information / eligibility
Status Completed
Enrollment 15
Est. completion date December 31, 2021
Est. primary completion date May 31, 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 21 Years to 50 Years
Eligibility Inclusion Criteria: - Current cannabis use - Able to give informed consent and perform study procedures - Women practicing an effective form of birth control - English speaking Exclusion Criteria: - Presence of any clinically significant medical diagnoses - History of heart disease and cardiac risk factors, severe chronic obstructive pulmonary disease, uncontrolled hypertension, or diabetes - Current parole or probation - Certain psychiatric diagnoses - Current pregnancy or lactation

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Lorcaserin
Lorcaserin 10mg BID
• Placebo
Placebo capsule BID
• Marijuana
Smoked marijuana cigarette

Locations
Country Name City State
United States New York State Psychiatric Institute New York New York

Sponsors (2)
Lead Sponsor Collaborator
New York State Psychiatric Institute National Institute on Drug Abuse (NIDA)

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Cannabis Self-administration Number of cannabis puffs participant chooses to smoke. 14 days
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