A Comparison of Post-Operative Analgesia Requirements In Recreational Cannabis Users Versus Cannabis Naïve Inflammatory Bowel Disease Patients

Cannabis Use, Opioid Consumption Clinical Trial

Official title:

A Comparison of Post-Operative Analgesia Requirements In Recreational Cannabis Users

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04055662
• Other study ID #: 2108.2.7
• Status: Completed
• Start date: August 1, 2019
• Est. completion date: March 30, 2020

Study information

• Verified date: August 2019
• Source: Mount Sinai Hospital, Canada
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Cannabis is a drug that is widely used for recreational purpose. In most patients undergoing surgery, opioids are the most widely used mode of pain relief, during and following surgery. Anecdotally it has been observed that cannabis users required unexpectedly high doses of opioids. The purpose of this study is to compare opioid requirements between cannabis users and non- users after the surgery. Currently, post-operative opioid doses are determined based on various patient factors such as pre-operative opioid use, patient weight, age and sensitivity to opioids during surgery. Patients' requirements may be underestimated and opioid regimens need to be escalated in the first 24 hours in order to alleviate uncontrolled pain in cannabis users. Better understanding of the impacts of cannabis use on post-operative opioid requirements would help the Acute Pain Service optimize post-operative pain management for patients who use cannabis pre-operatively.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: March 30, 2020
• Est. primary completion date: March 30, 2020
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

1. Consent to participate and signed consent form.

2. Age: 18-65 years.

3. Elective IBD bowel surgery under general anesthesia.

4. PCA use.

Related Conditions & MeSH terms

• Cannabis Use, Opioid Consumption
• Marijuana Abuse

Locations

Country	Name	City	State
Canada	Sinai Health System	Toronto	Ontario

Sponsors (1)

Lead Sponsor	Collaborator
Mount Sinai Hospital, Canada

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Opioid consumption	Amount of morphine equivalents on PCA	2 years