Social and Emotional Brain Function in Cannabis Users

Cannabis Dependence Clinical Trial

Official title:

Long-term Effects of Cannabis Use on Social and Emotional Brain Processes in Dependent Cannabis Users After a 28 Day Abstinence Period

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02711371
• Other study ID #: ART_Can_01
• Status: Completed
• Phase: N/A
• First received: March 4, 2016
• Last updated: February 1, 2017
• Start date: July 2015
• Est. completion date: December 2016

Study information

• Verified date: February 2017
• Source: University of Electronic Science and Technology of China
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of this functional magnetic resonance imaging (fMRI) study is to find out whether and how social and emotional brain function are altered in dependent cannabis users relative to healthy non-using control subjects after a 28 supervised abstinence period. Previous research in cannabis users has predominantly focused on cognitive functions. Moreover, studies have implicated that observed deficits in cannabis users may regenerate after a prolonged abstinence period. Findings might provide important information with respect to relapse vulnerability.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 43
• Est. completion date: December 2016
• Est. primary completion date: December 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Cannabis dependence according to DSM 4 criteria

• 28 days of supervised abstinence

Exclusion Criteria:

• other DSM 4 diagnosis

• neurological disorders

Related Conditions & MeSH terms

• Cannabis Dependence
• Marijuana Abuse

Intervention

Other:
• fMRI

Locations

Country	Name	City	State
Germany	University of Bonn / Department of Psychiatry	Bonn	NRW

Sponsors (3)

Lead Sponsor	Collaborator
University of Electronic Science and Technology of China	German Research Foundation, University Hospital, Bonn

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	fMRI neural activation patterns of social-emotional brain processes after 28 day abstinence	Activity patterns in core regions of the emotion processing & addiction-related brain networks (e.g. striatal regions, insular cortex, prefrontal cortex) will be assessed after 28-days of abstinence. Alterations will be determined by comparison with matched non-drug using controls	one timepoint = fMRI assessment after 28 day abstinence period
Secondary	Ratings of subjective experience (pleasantness, rewarding value) will be assessed after 28 days of abstinence	Self-reported ratings of pleasantness & rewarding value during soft-pleasant touch.	one timepoint = during fMRI assessment after 28 day abstinence period
Secondary	Relapse interview assessed with Timeline-Followback Method	Association between fMRI neural correlates and drug use during follow up period as predictor of relapse	one timepoint = 24 months post-fMRI-session