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A Trial of N-Acetylcysteine (an Over-the-Counter Medicine) in Adolescents Who Smoke Marijuana

Cannabis Dependence Clinical Trial

Official title:
A Controlled Trial of N-Acetylcysteine (NAC) in Cannabis Dependent Adolescents

Clinical Trial Summary

This study is investigating how N-Acetylcysteine (NAC), an over-the-counter medication, will reduce marijuana use when combined with Contingency Management, a behavioral treatment. It is hypothesized that marijuana dependent adolescents who are treated with NAC will use less marijuana during treatment when compared to adolescents who receive a placebo.

Clinical Trial Description

This protocol involves investigation of N-Acetylcysteine (NAC) as a pharmacological treatment for cannabis dependence in adolescents. While recent advances have been made in psychosocial treatments for cannabis dependent adolescents, minimal work has been done to investigate the potential adjunctive role for pharmacotherapy in treatment. NAC is an inexpensive, over-the-counter agent with a favorable tolerability profile in adults and children, in common use since FDA approval in 1963. Preclinical and preliminary clinical research in adults suggests a role for NAC in addiction treatment via glutamate modulation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01005810
Study type Interventional
Source Medical University of South Carolina
Contact
Status Completed
Phase Phase 2
Start date September 2009
Completion date August 2011
View Details
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