Candidiasis Clinical Trial
Official title:
PROCAS: Study Observational Prospective and Multicenter to Determine the Clinic Effectiveness and the Safety of Caspofungin Acetate (CANCIDAS®) in the Treatment of Invader Fungal Infection
Verified date | May 2009 |
Source | PETHEMA Foundation |
Contact | n/a |
Is FDA regulated | No |
Health authority | Spain: Generalitat Valenciana |
Study type | Observational |
We wanted to determine the efficacy and the safety of caspofungin acetate (CANCIDAS®) in the treatment of invader fungal infection (IFI) specifically, Invasive Candidiasis (CI) in adults patients without neutropenia and Invasive Aspergillosis (AI) in adults patients who are refractory to or intolerant of other therapies (i.e., amphotericin B, lipid formulations of amphotericin B, and/or itraconazole).
Status | Completed |
Enrollment | 320 |
Est. completion date | February 2008 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Female and male with 18 years old at least. - Diagnosis of AI or CI. It will be based in Clinical History, signs and symptoms that the patient takes, discovery of studies of radiology and results of cultivation and/or studies of anatomopathology positives for Candida spp. or Aspergillus spp. - Patients with AI, must be refractory to or intolerant of other therapies antifungal used in the hospital. - Patients with CI, must be or not refractory to or intolerant of other therapies antifungal used in the hospital. Exclusion Criteria: - Patients with diagnosis uncertain based in one or more of next criterions: Cultivation positive for Candida in an only localization (urine, spittle, end/current of catheter; osteomyelitis or endocarditis by Candida without treatment appropriated surgical; infection by Candida of prosthetic material without retired of the same; positive blood cultive for Candida in appearance of vascular prosthesis; allergic lung Aspergillosis; and aspergilloma or aspergillosis eye without treatment appropriated surgical). - Allergic / hypersensitivity to caspofungin. - Insufficiency several liver (rate of Chile-Pugh >9). - Prediction of survival <5 days. - Pregnant or breast feeding. - Previous Participation of patient in this study. - Presence of other disease or any condition that it can mix up the interpretation of results or create risks. - Previous Participation of patient in other clinical study that it involve the administration of a drug in investigation in the 14 days previous to your inclusion in the study or during the administration of caspofungin. We can include patients took with antineoplastic drugs in research whenever at lefts a Investigator Coordinator authorizes it before |
Observational Model: Case-Only, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Spain | Hospital General de Alicante | Alicante | |
Spain | Hospital Germans Trias i Pujol | Badalona | Barcelona |
Spain | Hospital Clínico y Provincial de Barcelona | Barcelona | |
Spain | Hospital de la Santa Creu i Sant Pau | Barcelona | |
Spain | Hospital vall d'Hebrón | Barcelona | |
Spain | Hospital Puerta del Mar | Cádiz | |
Spain | Hospital general de Castellón | Castello | Castellón |
Spain | Complejo Hospitalario Reina Sofía | Córdoba | |
Spain | Hospital Universitario Virgen de las Nieves | Granada | |
Spain | Institut Català d'Oncología | Hospitalet de Llobregat | Barcelona |
Spain | Area Hospitalaria Juan Ramón Jimenez | Huelva | |
Spain | Hospital general de Jerez de la Frontera | Jerez de la Frontera | |
Spain | Hospital Juan Canalejo | La Coruña | |
Spain | . Hospital Clínico Universitario Virgen de la Victoria | Málaga | |
Spain | Hospital Carlos Haya | Málaga | |
Spain | Xarxa assistencial de Manresa | Manresa | Barcelona |
Spain | Hospital Son Dureta | Palma de Mallorca | |
Spain | Hospital Son Llàtzer | Palma de Mallorca | |
Spain | Hospital Universitario Marqués de Valdecilla | Santander | |
Spain | Complejo Hospitalario Universitario de Santiago | Santiago de Compostela | La Coruña |
Spain | Hospital Universitario Virgen del Rocío | Sevilla | |
Spain | Hospital Universitari de Tarragona Joan XXIII | Tarragona | |
Spain | Hospital Verge de la Cinta | Tortosa | Tarragona |
Spain | Hospital Clínico de Valencia | Valencia | |
Spain | Hospital La Fe | Valencia | |
Spain | Hospital Universitario Dr. Peset | Valencia | |
Spain | Complejo Hospitalario Xeral-Cies | Vigo |
Lead Sponsor | Collaborator |
---|---|
PETHEMA Foundation | GTEI, SEMICYUC |
Spain,
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* Note: There are 49 references in all — Click here to view all references
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