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Safety and Efficacy of Interferon-Gamma 1b in Patients With Candidemia

Candidemia Clinical Trial

Official title:
Safety and Efficacy of Recombinant Interferon-Gamma 1b (rIFN-Gamma 1b) Given With Standard Therapy in Patients With Candidemia

Clinical Trial Summary

A multi-center open label adaptive randomized interventional phase 2 study to evaluate safety and efficacy of rIFN-y treatment in patiens with candidemia.

Clinical Trial Description

A multi-center open label adaptive randomized interventional phase 2 study to evaluate safety and efficacy of rIFN-y treatment in patiens with candidemia. Patients will be randomized 1:1 between intervention (rIFN-y immunotherapy, subcutaneous dose of 100miicrogram thrice weekly for two weeks or until hospital discharge) in addition to standard of care versus controls (standard of care). Standard of care antifungal therapy is according to ESCMID/EFISG (Europe) or IDSA (US) guidelines. We will assess the effect on clinical outcome and investigate relevant biomarkers that can guide this immunotherapeutic approach. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04979052
Study type Interventional
Source Radboud University Medical Center
Contact Frank vd Veerdonk, Dr.
Phone 0031243618819
Email frank.vandeveerdonk@radboudumc.nl
Status Recruiting
Phase Phase 2
Start date March 31, 2022
Completion date January 2025
View Details
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