Candida Albicans Infection Clinical Trial
Official title:
Evaluation of Candida Albicans Growth on Bre.Flex Versus PEEK ( Polyether Ether Ketone ) Denture Base in Bilateral Maxillary Bounded Partial Denture (Randomized Clinical Trial)
This study evaluate Candida Albicans growth on Bre-Flex versus PEEK denture base in Bilateral Maxillary bounded partial denture , half of patients will receive a framework with breflex denture base and the other half will receive a framework with PEEK denture base then evaluate the Candida growth
Peek and Bre.flex are both new material that introduced to the market recently with great
benefits like aesthetics and bio-compatibility but which material has less candida growth ?
Bre.flex is a nylon-based thermoplastic material, composed of nylon polyamide 12
(polyamide).Nylon exhibits high physical strength, heat resistance and chemical resistance.
It can be easily modified to increase stiffness and wear resistance. Nylon resin can be
semi-translucent and provides excellent esthetics but it is a little more difficult to adjust
and polish.
Despite of its highly esthetics features, Nylon still suffers from surface roughness that
increase the colonization for candida but less than heat cured acrylic Recently, PEEK is
introduced as a removable prosthesis material due to its high mechanical and biological
properties but further clinical studies or systematic reviews focusing on the use of PEEK
dentures are needed.
The patient will be treated in visits designated as follows:
Visit 1: Preoperative records, clinical, radiographic examination (panoramic and periapical
x-rays for evaluation the crown-root ratio, the apical condition of the abutment and their
alveolar bone support of abutment) and primary impression will be performed with irreversible
hydro-colloid impression material (alginate), The impressions will be poured with type IV
dental stone to obtain diagnostic casts.
Visit 2: Maxillary Face-bow will be recorded. The diagnostic casts will be mounted on semi
adjustable articulator in centric occluding relation to evaluate the inter arch distance and
occlusal plane.
Visit 3: primary surveying is performed. Special trays will be constructed and Mouth
preparation will be performed by preparing guiding planes and rests seats on the abutments.
Final impression will be taken by elastomeric impression material. The impression will be
poured into type IV dental stone in order to obtain master cast. The master cast will be
surveyed. The proposed design will be as follows: framework for edentulous areas on both
sides connected with palatal strap. Aker's clasp on all abutments with buccal retention.
Visit 4: the metal framework is tried into the patient's mouth. Jaw relation is recorded.
Visit 5: The framework will be tried in with acrylic teeth in patient's mouth. Visit 6: the
denture base of the partial denture will be processed incorporation with the metal framework
into the two different materials to be evaluated. The first group will receive the partial
denture in which the metal framework incorporated with the denture base fabricated from PEEK
material. The second group will receive the partial denture in which the metal framework
incorporated with the denture base material fabricated from BRE-FLEX.
Visit7, 8, 9: clinical measurement will be performed for one month in three visits.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT06146504 -
Clinical Study to Evaluate the Efficacy of an Anti-Fungal Supplement
|
N/A | |
| Active, not recruiting |
NCT04837664 -
Curcumin; Rose Bengal; Denture Stomatitis
|
Phase 3 | |
| Not yet recruiting |
NCT05289375 -
Efficacy of the Vacucis Candida® Autovaccine
|
N/A |