Cancer of Unknown Primary Site Clinical Trial
Official title:
Carcinoma of Unknown Primary (CUP): A Comparison Across Tissue and Liquid
Patients with Carcinoma of Unknown Primary (CUP) have widespread cancer at diagnosis however the specific site of origin cannot be found, despite significant testing, making it difficult to treat. CUP has a poor prognosis; it is the 6th most common cause of cancer death in the UK. To date there have been limited studies investigating molecular genomics in CUP patients, resulting in limited evidence to evaluate whether genomic profiling has added value over and above the standard diagnostics provided in the NHS. As a result, our project will aim to; - Assess genomic sequencing (both in tissue and blood) for the diagnosis and treatment guidance in CUP patients including a comparison of the effectiveness of tissue and blood based biomarkers - Collect evidence to further develop technology that predicts an individual's response to a treatment - Develop innovative systems of clinical data capture in patients with CUP - Investigate novel biomarkers to determine the primary tumour location Approximately 120-140 CUP patients will be recruited across 7 UK NHS sites. Tumour samples will be collected from patients undergoing a standard of care procedure OR medically fit patients with accessible tumour. Archival tumour may also be obtained. Some samples will be stored for future translational research. Sequencing results alongside clinical data will be discussed by a multi-disciplinary CUP Molecular Tumour Board. They will provide oversight on the nature, clinical significance and relevance of the results. They will inform the local CUP team of any "actionable" genetic changes, which could potentially direct selection of a targeted therapy trial for that patient. Sequential blood samples will be collected to investigate genetic characteristics that may be able to predict response to therapy. The aggregated anonymised data will be made publicly available following completion of this trial.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03278600 -
Tissue-of-origin Directing Therapy in Patients With Cancer of Unknown Primary
|
Phase 3 | |
| Recruiting |
NCT04504604 -
TCF-001 TRACK (Target Rare Cancer Knowledge) Study
|
N/A | |
| Completed |
NCT03053466 -
APL-501 Study for Select Advanced or Relapsed/Recurrent Solid Tumors
|
Phase 1 | |
| Recruiting |
NCT04952103 -
Real World Study of Diagnosis and First-line Treatment Among Patients With Cancer of Unknown Primary in China
|
||
| Recruiting |
NCT04969835 -
A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours
|
Phase 1 | |
| Active, not recruiting |
NCT03498521 -
A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site
|
Phase 2 | |
| Completed |
NCT01845337 -
Study to Compare Cardiovascular Side Effects of Teysuno Versus Capecitabine
|
Phase 2 | |
| Recruiting |
NCT05263700 -
FAPI-CUP- Evaluating FAPI as a Novel Radiopharmaceutical for Cancer of Unknown Primary
|
N/A | |
| Active, not recruiting |
NCT03752333 -
Trial of Pembrolizumab in Cancer of Unknown Primary
|
Phase 2 | |
| Completed |
NCT05841966 -
Surgeon-performed Intraoperative Transoral Ultrasound for Cancer of Unknown Primary
|
N/A | |
| Recruiting |
NCT04131621 -
Nivolumab/Ipilimumab in Second Line CUP-syndrome
|
Phase 2 | |
| Recruiting |
NCT04459273 -
Prospective Exploratory Study of FAPi PET/CT With Histopathology Validation in Patients With Various Cancers
|
Phase 1 | |
| Active, not recruiting |
NCT05024968 -
Sintilimab in Cancer of Unknown Primary
|
Phase 2 |