Cancer Colorectal Clinical Trial
Official title:
French Colorectal ESD Cohort in Experts Centers
Initially developed in Japan for the treatment of endemic superficial gastric cancers, endoscopic submucosal dissection (ESD) allows resection of pre-neoplastic and neoplastic lesions of the digestive tract into a single fragment. It allows a perfect pathological analysis, and decreases the rate of recurrence of the adenoma to less than 2%. However, this procedure, which is technically more challenging, is also more risky (perforation rate at 4% vs. 1% for WF-EMR) and longer. Submucosal dissection is also more expensive in terms of equipment, but this difference can be offset by the cost of the high number of iterative colonoscopies required in patients who have had endoscopic resection by WF-EMR. Scientific debate is agitating the Western world1,2 and Japanese experts do not perform WF-EMR anymore, whereas no comparative prospective study has compared these two procedures. A lot of centers in France performed colorectal ESD even for benign lesions and nationwide data about safety and efficiency is required to confirm the place of ESD for treatment of large superficial colorectal lesions.
Initially developed in Japan for the treatment of endemic superficial gastric cancers, endoscopic submucosal dissection (ESD) allows resection of pre-neoplastic and neoplastic lesions of the digestive tract into a single fragment. It allows a perfect pathological analysis, and decreases the rate of recurrence of the adenoma to less than 2%. However, this procedure, which is technically more challenging, is also more risky (perforation rate at 4% vs. 1% for WF-EMR) and longer. Submucosal dissection is also more expensive in terms of equipment, but this difference can be offset by the cost of the high number of iterative colonoscopies required in patients who have had endoscopic resection by WF-EMR. Scientific debate is agitating the Western world1,2 and Japanese experts do not perform WF-EMR anymore, whereas no comparative prospective study has compared these two procedures. A lot of centers in France performed colorectal ESD even for benign lesions and nationwide data about safety and efficiency is required to confirm the place of ESD for treatment of large superficial colorectal lesions. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05536089 -
ctDNA Methylation Application in Postoperative Relapse and Adjuvant Chemotherapy Efficacy Evaluation
|
||
Active, not recruiting |
NCT04392479 -
TWICE-IRI: Optimization of Second-line Therapy With Aflibercept, Irinotecan (Day 1 or Day 1,3), 5-Fluorouracile and Folinic Acid in Patients With Metastatic Colorectal Cancer. A Randomized Phase III Study.
|
Phase 3 | |
Not yet recruiting |
NCT05577143 -
Blood Screening for Adult Colorectal Cancer
|
||
Active, not recruiting |
NCT05585866 -
Propofol and Sevoflurane Anesthesia in Colorectal Cancer Surgery: Incidence of Acute Kidney Injury
|
||
Recruiting |
NCT05573022 -
Impact of a Patient Decision Aid Intervention
|
N/A | |
Completed |
NCT02931825 -
Identification of High Risk People for Colorectal Cancer and Evaluation of a Specific Surveillance System
|
N/A | |
Recruiting |
NCT03301493 -
Genomic Testing and Resulting Medical Decisions
|
||
Not yet recruiting |
NCT05791747 -
Representations, Beliefs and Attitudes Towards Hypnosis in Patients Followed for Colorectal Cancer
|
||
Recruiting |
NCT05830097 -
A Study of Bi-Ligand-Drug Conjugate CBP-1019 in Patients With Advanced Solid Tumors
|
Phase 1/Phase 2 | |
Not yet recruiting |
NCT06324409 -
ImmigrantScreen Telephone Reminder Trial in Colorectal Cancer Screening
|
N/A | |
Recruiting |
NCT04258813 -
Onco-primary Care Networking to Support TEAM-based Care
|
N/A | |
Active, not recruiting |
NCT05939440 -
Interventions to Decrease Financial Toxicity
|
N/A | |
Completed |
NCT04548765 -
Evaluation of Letters Promoting Colorectal Cancer Testing
|
N/A | |
Recruiting |
NCT04189055 -
Cetuximab as Salvage Therapy in Patients With Neo Wild-type RAS/RAF Metastatic Colorectal Cancer With Liver Metastases.
|
Phase 2 | |
Withdrawn |
NCT04345952 -
Calm for Cancer Patients Receiving Chemotherapy
|
N/A | |
Completed |
NCT04280393 -
Effectiveness and Safety of the Colonoscopy Assisted by Endocuff vs. Standard in the Colorectal Cancer Screening
|
N/A | |
Not yet recruiting |
NCT06231576 -
Digital Home-Based Prehabilitation Before Surgery
|
N/A | |
Recruiting |
NCT04874883 -
Effect of the Use of Symbiotics in Patients With Colon Cancer
|
Phase 4 | |
Completed |
NCT04074460 -
Volatile Anaesthesia and Perioperative Outcomes Related to Cancer Feasibility Study
|
Phase 4 | |
Not yet recruiting |
NCT06191185 -
IMProving Adherence to Colonoscopy Through Teams and Technology
|
N/A |