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Cancer Colon clinical trials

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NCT ID: NCT06391749 Recruiting - Cancer, Breast Clinical Trials

Clinical Validation of an MCED Test in Symptomatic Populations (K-ACCELERATE)

K-ACCELERATE
Start date: May 2024
Phase:
Study type: Observational

To evaluate the diagnostic performance of blood-based SPOT-MAS test in symptomatic individuals, the investigators sought to launch a prospective multicenter study, named K-ACCELERATE. The study aims to recruit 1,000 participants who develop symptoms and signs specific to the top five common cancer types including breast, colorectal, gastric, liver and lung cancer. Primary objective: Evaluate the performance of the SPOT-MAS test in detecting cancer in symptomatic populations. Secondary objectives: Evaluate the feasibility of incorporating SPOT-MAS as a triage test into primary care to increase the detection rates of malignant cancer while minimizing unnecessary referrals to invasive procedures.

NCT ID: NCT06119425 Recruiting - Cancer Colon Clinical Trials

Blood-Based Colorectal Cancer (CRC) Screening Implementation Into Clinical Practice Highlands

Start date: October 12, 2023
Phase: N/A
Study type: Interventional

This is a prospective implementation study that will include patients that are identified as being average risk for colorectal cancer (CRC) according to USPSTF guidelines and who have opted to be screened for CRC. The purpose of this study is to understand implementation of a noninvasive screening test in primary care and internal medicine clinical settings, and the impact on patient acceptability and adherence of CRC screening.

NCT ID: NCT05177484 Recruiting - Cancer Colon Clinical Trials

Perioperative Iron for Colorectal Cancer (PICoC Study)

PICoC
Start date: May 30, 2022
Phase: Phase 3
Study type: Interventional

The PICoC study aims to investigate whether oral ferric maltol given postoperatively offers an improvement in patient and clinician reported outcomes compared to standard care.

NCT ID: NCT04972994 Recruiting - Cancer Colon Clinical Trials

Laparoscopic Colectomies In Management of Colonic Cancers

Start date: June 1, 2021
Phase: N/A
Study type: Interventional

The aim of this study is to compare the Surgical outcomes after laparoscopic intracorporeal versus extracorporeal anastomosis for right and left hemicolectomies in management of colonic cancers .

NCT ID: NCT03976960 Recruiting - Cancer Colon Clinical Trials

Clinical and Biological Database in Colon Cancer and Colic Tumors

BCBCOLON
Start date: September 19, 2018
Phase: N/A
Study type: Interventional

Developement of a clinical and biological database in colon cancer and colic tumors in order to better understand tumor invasion and metastatic scattering processes. The investigators hope that a better understanding of tumoral invasion process will lead to the discovery of new biomarkers and new drugs.

NCT ID: NCT03722121 Recruiting - Chemotherapy Clinical Trials

Is the Distance of Patients From Rouen University Hospital Influencing the Time Between Colectomy and First Chemotherapy Cure for Colon Cancer?

DICHIMIO
Start date: March 23, 2017
Phase:
Study type: Observational

This project has for objective to demonstrate that the increase of the distance "Patient home - center of treatment" may be associated with significant, other noticeable, noted events. This distance may also be available in the Rouen University Hospital. The study of the association in this distance and the delay in initiating chemotherapy after surgery in patients treated at the CHU correspond to a pilot study prior to the completion of the analysis at the regional scale.

NCT ID: NCT02542670 Recruiting - Cancer Colon Clinical Trials

Genetic Variants of Selected Genes in Colo-Rectal Cancer Patients.

Start date: July 2015
Phase: N/A
Study type: Observational

Colorectal cancers (CRC) are the third most common human malignancy, and are also the leading cause of cancer related deaths worldwide. Early detection of premalignant lesions such as adenomatous polyps has decreased the risk of CRCs; however, cases which are initially undetected and progress to advanced CRC with distant metastasis are still unfortunately incurable. The development of CRC is a complex and heterogeneous process arising from an interaction between multiple etiological factors, including genetic factors and environmental factors such as diet and lifestyle. The challenges are to understand the molecular basis of individual susceptibility to colorectal cancer and to determine factors that initiate the development of the tumor, drive its progression, and determine its responsiveness or resistance to antitumor agents. Next generation sequencing(NGS)-driven genomic studies are already reporting novel features of cancer genomes beyond the traditional mutational categories. Recent advance in sequencing technology has enabled comprehensive profiling of genetic alterations in CRC.These methods are facilitating an increase in the efficiency and resolution of detection of each of the principal types of somatic cancer genome alterations, including nucleotide substitutions, small insertions and deletions, copy number alterations, chromosomal rearrangements,DNA methylation sequencing such as bisulfite-sequencing and microbial infections. Besides the microsatellite instability (MSI), some researchers reported novel mitochondrial mutations in the cancer genomes. NGS technology will help the investigators for understanding of entire CRC genomes and the obtained knowledge will lead to a better diagnosis and personalized targeted therapeutics for CRC management