Calcium Nephrolithiasis Clinical Trial
Official title:
Relation Between Bone Mineral Density and the Regulation of Mineral Metabolism in Renal Stone Formers
Accumulating evidence indicated that renal calcium stone formers often exhibit a low bone density. Therefore we want to test the hypothesis, that the mineral (calcium) metabolism is differently regulated in calcium stone formers with low as opposed to high bone density.
There is epidemiological evidence associating renal calcium stones and decreased bone
mineral density (BMD). The decreased BMD in calcium stone formers is linked to
hypercalciuria and both subtypes, fasting as well as absorptive hypercalciuria are
associated with a diminished BMD. Higher 1,25-vitamin D plasma concentrations and lower PTH
levels are encountered under free-choice diet conditions in patients diagnosed with
absorptive and fasting hypercalciuria when compared to normocalciuric stone formers. Reports
studying the BMD of stone formers and its link with mineral metabolism variables and urinary
calcium excretion under different calcium intakes are rare.
We hypothesize now that PTH and 1,25-vitamin D change differently when calcium stone formers
with high, intermediate and low BMD are challenged by a low calcium diet.
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Observational Model: Case-Only