The Effects of Caffeine on Heart Rate and Heart Rate Variability

Caffeine Clinical Trial

Official title:

The Effects of Caffeine Supplementation on Heart Rate and Heart Rate Variability at Rest and During Submaximal Exercise

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05521386
• Other study ID #: StMarysUC5
• Status: Not yet recruiting
• Phase: N/A
• Start date: September 1, 2022
• Est. completion date: April 30, 2023

Study information

• Verified date: August 2022
• Source: St Mary's University College
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

In previous research we have shown that an acute caffeine dose of 5 mg/kg body mass reduces heart rate at rest and during low intensity exercise, with the effect dissipating as exercise intensity increases. If, as suspected, the effect at rest and at low intensities is due to an effect of caffeine on parasympathetic activity, this is likely to be reflected in an increase in heart rate variability (the beat-to-beat fluctuation in heart rate). The aim of this study is therefore to investigate the effect of caffeine on heart rate and heart rate variability at rest and during submaximal exercise.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 16
• Est. completion date: April 30, 2023
• Est. primary completion date: March 31, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 55 Years

Eligibility

Inclusion Criteria:

• Trained cyclists

Exclusion Criteria:

• Injured or a contraindicative medical condition

Related Conditions & MeSH terms

• Caffeine

Intervention

Drug:
• Caffeine
Single pill in an acute dose of 5 mg per kg of body mass
• Placebo
Single pill in an acute dose of 5 mg per kg of body mass

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
St Mary's University College

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Heart rate variability	Change from baseline in heart rate variability measured at rest and at five different exercise intensities (40, 50, 60, 70 and 80% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer	From baseline to completion, up to 31 days
Secondary	Heart rate	Change from baseline in heart rate measured at rest and at five different exercise intensities (40, 50, 60, 70 and 80% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer	From baseline to completion, up to 31 days