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A Dose Escalation Study of AV-380 in Metastatic Cancer Patients With Cachexia

Cachexia Clinical Trial

Official title:
A Phase 1 Dose Escalation Study of AV-380 in Combination With Standard of Care Chemotherapy in Metastatic Cancer Patients With Cachexia and Elevated GDF-15 Levels

Clinical Trial Summary

This open label ascending dose study is designed to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of AV-380 in metastatic cancer patients with Cachexia. AV-380 is an immunoglobulin (Ig) G1 monoclonal antibody (mAb) intended to bind circulating human growth differentiation factor 15 (GDF-15), a cytokine involved in cancer-induced cachexia.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05865535
Study type Interventional
Source AVEO Pharmaceuticals, Inc.
Contact AVEO Clinical Trials Office
Phone (857)400-0101
Email clinical@aveooncology.com
Status Recruiting
Phase Phase 1
Start date June 13, 2023
Completion date September 30, 2025
View Details
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