A Phase 1 Study of AV-380 in Healthy Subjects

Status Completed

Clinical Trial Summary

This double-blinded, placebo-controlled, single ascending dose (SAD) study is designed to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity in healthy subjects of a single dose of AV-380. AV-380 is an immunoglobulin (Ig) G1 monoclonal antibody (mAb) intended to bind circulating human growth differentiation factor 15 (GDF-15), a cytokine involved in cancer-induced cachexia.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Cachexia

Clinical Trial Details

NCT number	NCT04815551
Study type	Interventional
Source	AVEO Pharmaceuticals, Inc.
Contact
Status	Completed
Phase	Phase 1
Start date	February 22, 2021
Completion date	January 14, 2022

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