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Acute Normovolemic Hemodilution in High Risk Cardiac Surgery Patients. — ANH  

C.Surgical Procedure; Cardiac Clinical Trial

Official title:
Acute Normovolemic Hemodilution in High-risk Cardiac Surgery Patients. A Multicentre Randomized Trial.

Clinical Trial Summary

Transfusions are one of the most overused treatments in modern medicine, and saving blood is one important issue all around the world. Cardiac surgery makes up a large percentage of the overall blood components consumption in surgery. Acute normovolemic hemo-dilution (ANH) is a well-known strategy which has been used for years without the support of high quality evidence based medicine to improve post-cardiopulmonary bypass coagulation and reduce red blood cells (RBC) transfusion. We designed a multicenter randomized controlled trial to investigate the effect of ANH in reducing the number of cardiac surgery patients receiving RBC transfusions during hospital stay. We will randomize 2000 patients to have sufficient power to demonstrate a 20% relative and 7% absolute risk reduction in the number of patients' RBC transfusion. If the results of the study will confirm our hypothesis, this will have a great impact on blood management in cardiac operating room.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03913481
Study type Interventional
Source Università Vita-Salute San Raffaele
Contact Giovanni Landoni, Prof
Phone +39022643
Email landoni.giovanni@hsr.it
Status Recruiting
Phase N/A
Start date April 15, 2019
Completion date March 2025
View Details
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