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Organ Protective Effect of Cetirizine In Patients With Severe Burns

Burns Clinical Trial

Official title:
Organ Protective Effect of Histamine H1 Receptor Antagonist In Patients With Severe Burns: A Clinical Study

Clinical Trial Summary

This prospective clinical trial aims to investigate the organ protective effects of cetirizine in patients with severe burns.

Clinical Trial Description

This is a prospective, randomized, single-blind, parallel-controlled clinical trial. The global objective is to compare the organ protective effects of the sedation and analgesia regimen (midazolam, fentanyl) with the modified sedation and analgesia regimen (midazolam, fentanyl, cetirizine) in patients with severe burns (≥30% TBSA). Participants will receive the intervention from admission to 72 hours post-burn. Researchers will take the APACHE II scores on days 7 after admission as the main outcomes. Researchers will also take other supplementary examination results into account, including liver enzyme, myocardial enzyme, renal function, haemodynamic index, coagulation function, and pulmonary interstitial edema. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06126991
Study type Interventional
Source Ruijin Hospital
Contact Yan Liu
Phone 021-64370045
Email rjliuyan@126.com
Status Recruiting
Phase Phase 1/Phase 2
Start date January 23, 2024
Completion date December 31, 2025
View Details
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