Burns Clinical Trial - The Effect of Aerobic Exercise on

Status Recruiting

Clinical Trial Summary

In the study, it was planned to investigate the Effect on Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Lymphocyte-Monocyte Ratio in burn patients by creating 2 different exercise groups. The aim of this study is to investigate the effect of aerobic exercise on neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and lymphocyte-monocyte ratios in burn patients.

Clinical Trial Description

Burn injuries are a trauma that is seen due to causes such as flame, hot liquid, radiation, chemical, cold or electricity and causes destruction in the skin and/or organic tissues due to energy transfer. Burn injuries cause profound hypermetabolic and catabolic responses that can last for months or even years. Especially in burn patients with involvement of more than 20% of the total body surface area (TVSA), lipolysis, proteolysis, glycolysis, and hyperdynamic and high fever, Many severe hypermetabolic responses are seen. These hypermetabolic responses seen in patients lead to decrease in lean muscle mass, inflammation, deterioration of cardiovascular, endocrine and glucose systems, coagulopathy, deterioration of fibrinolytic activity, decrease in functional capacity, delay in wound healing, weakening of the immune system and serious mortality. In severely burned patients, the resting metabolic rate may exceed 140% of normal. Various parameters are used to monitor all these systemic responses of the burn. Various scores have been developed in the clinic, especially using inflammatory cells such as neutrophils, monocytes, lymphocytes and platelets. In the literature, major diseases such as cancer, heart diseases and burns It has been stated that a systemic inflammation occurs due to trauma and calculations of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and lymphocyte-monocyte ratios are prognostic indicators. Exercise in burn patients; It is a highly effective method with high evidence value in minimizing the effects of the hypermetabolic response caused by the burn, preventing muscle atrophy, increasing the pulmonary function and functional capacity, reducing the inflammatory response and healing the burn. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06013553
Study type	Interventional
Source	Hasan Kalyoncu University
Contact	MURAT A ÇINAR, DR
Phone	+905331639319
Email	muratalicinar@gmail.com
Status	Recruiting
Phase	N/A
Start date	August 1, 2023
Completion date	October 30, 2023

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See also
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Completed	`NCT02681757` - Comparison of Mepitel Ag vs Antibiotic Ointment Used With Soft Cast Technique for Treatment of Pediatric Burns	N/A
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Completed	`NCT01214811` - Open Multi-centre Investigation to Evaluate Signs and Symptoms of Local Inflammation/Infection on Chronic Ulcers and Partial Thickness Burns When Using Mepilex Border Ag as an Anti-microbial Wound Dressing	Phase 3
Completed	`NCT01061502` - Efficacy Study of a Bioelectric Dressing to Treat Skin Graft Donor Site Wounds	Phase 1/Phase 2
Terminated	`NCT00822796` - Thermogard™ Efficacy Trial	N/A
Terminated	`NCT00824681` - Effect of Music Therapy on Families of Burn Patients	Phase 1
Terminated	`NCT00634166` - Effects of Therapy With Sulfamylon® 5% Topical Solution Compared to a Historical Control Group	Phase 4
Terminated	`NCT00464386` - Continuous Glucose Monitoring (POC) in the ICU	N/A
Withdrawn	`NCT00216983` - Proline Metabolism in Severely Burned Patients: Effect of Modulated Parenteral Feeding	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

The Effect of Aerobic Exercise on Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Lymphocyte-Monocyte Ratio in Burn Patients: A Randomized Controlled Study

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms