The Mechanical Properties of Burned Muscles

Burns Clinical Trial

Official title:

The Investigation of Muscle Mechanical Properties in Burned Patients.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04654572
• Other study ID #: 2018-05
• Status: Completed
• Phase: N/A
• Start date: June 6, 2018
• Est. completion date: August 20, 2020

Study information

• Verified date: December 2020
• Source: Hasan Kalyoncu University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The investigate of mechanical properties of muscles in burned patients.

Description:

The hypermetabolic response to severe burn is characterized by muscle protein catabolism. Current opinion states that the hypermetabolic state resolves soon after complete wound closure. Clinically, we have witnessed that burned patient appear to be hypermetabolic and catabolic long after full healing of their wounds. Our goal in this study was to determine muscle mechanical properties (tone, stiffness and elasticity) after burn.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 37
• Est. completion date: August 20, 2020
• Est. primary completion date: March 20, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 64 Years

Eligibility

Inclusion Criteria:

• burned patient

• major burn over %20 TBSA

Exclusion Criteria:

• Amputation

• Dead

• Systemic disease and abuse

Related Conditions & MeSH terms

• Burns
• Muscle Loss
• Stiffness
• Viscoelastic Properties

Intervention

Diagnostic Test:
• Myotonometric measurement
Myotonometric assessment can predict the muscle stiffness, tone and elasticity

Locations

Country	Name	City	State
Turkey	Hasan kalyoncu üniversity	Gaziantep

Sponsors (1)

Lead Sponsor	Collaborator
Hasan Kalyoncu University

Country where clinical trial is conducted

Turkey, 

References & Publications (3)

Gittings PM, Grisbrook TL, Edgar DW, Wood FM, Wand BM, O'Connell NE. Resistance training for rehabilitation after burn injury: A systematic literature review & meta-analysis. Burns. 2018 Jun;44(4):731-751. doi: 10.1016/j.burns.2017.08.009. Epub 2017 Oct 7. Erratum in: Burns. 2020 Aug;46(5):1240-1241. — View Citation

Ianieri G, Saggini R, Marvulli R, Tondi G, Aprile A, Ranieri M, Benedetto G, Altini S, Lancioni GE, Goffredo L, Bellomo RG, Megna M, Megna G. New approach in the assessment of the tone, elasticity and the muscular resistance: nominal scales vs MYOTON. Int J Immunopathol Pharmacol. 2009 Jul-Sep;22(3 Suppl):21-4. — View Citation

Porter C, Hardee JP, Herndon DN, Suman OE. The role of exercise in the rehabilitation of patients with severe burns. Exerc Sport Sci Rev. 2015 Jan;43(1):34-40. doi: 10.1249/JES.0000000000000029. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Stiffness	Myotonometric measurement was used to determine for muscle stiffness. Device has a probe that creates constant pre-excitations and generates short-term, low-force mechanical stimulations over skin. The stimulations induce damped natural oscillations in the tissue and the myoton device records these oscillations with an accelerometer. Muscle tone, elasticity, and stiffness are calculated separately by the device.	6 week
Primary	Elasticity	Myotonometric measurement was used to determine for muscle elasticity. Device has a probe that creates constant pre-excitations and generates short-term, low-force mechanical stimulations over skin. The stimulations induce damped natural oscillations in the tissue and the myoton device records these oscillations with an accelerometer. Muscle tone, elasticity, and stiffness are calculated separately by the device.	6 week
Primary	Tone	Myotonometric measurement was used to determine for muscle tone. Device has a probe that creates constant pre-excitations and generates short-term, low-force mechanical stimulations over skin. The stimulations induce damped natural oscillations in the tissue and the myoton device records these oscillations with an accelerometer. Muscle tone, elasticity, and stiffness are calculated separately by the device.	6 week