Burns Clinical Trial
Official title:
Volume Kinetics for Hyperoncotic Albumin in Burn Patients as Well as for Healthy Subjects
Treatment with colloidal solutions has during long time been a cornerstone within intensive
care. Lately, doubts have been raised about synthetic colloids, and the natural albumin has
been used more and more.
One of these solutions is the hyperoncotic "Albumin 20%". However there are still many
aspects of the physiological effects of hyperoncotic albumin, that are not known. In this
study physiological effects will be studied in burn patients and healthy subjects. The
colloid osmotic pressure and the increase of the plasma volume will be measured in 15 healthy
subjects and in 15 burn patients. The effect on the plasma volume will be studied using
hemoglobin as a marker of dilution. Colloids osmotic pressure and albumin concentration will
be measured directly and urin production will also be measured. Blood samples will be
collected during 4 to 5 hours to achieve a profile over the changes.
Healthy individuals are asked to refrain from eating and drinking the night before the study.
Two hours before study start, the subjects may take a sandwich and a glas to drink. Patients
will also be asked to keep the same rules unless they receive parenteral nutrition. Shortly
before the study, the subjects are asked to leave an urine sample.
After 15 minutes of rest the first bood samples are taken. An infusion 3 ml/kg bodyweight
Albumin 20% is given during 30 minutes. The first hour after study start (start of infusion)
blood samples are taken every 10 minutes. The following 4 hours another 9 blood samples are
collected. Hemoglobin, albumin and colloidosmotic pressure will be measured at every
occasion.
C-reactive protein, interleukin-6, Syndecan -1 as well as heparan sulfate, will be measured
before, after 1 hour and 5 hours after study start.
The total volume of blood collected will be 150 ml. If the study subjects have a low urin
output, acetated Ringers will be given at the end of the study. Liberal fluid intake is
recommended the same day and the next.
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