Burns Clinical Trial
Official title:
PRP on Children With Retractable Burn Sequelae Who Have Submitted Release of Burn Contractures and Skin Graft on Their Limbs. A Double-Blind Randomized Clinical Trial
Does the addition of Platelet-Rich Plasma (PRP) to release of burn contractures and skin graft on the limbs of children with retractable burn sequelae reduce the initial time of the compressive treatment and maintain or lower the graft's retraction?
Hypothesis:
1. The use of PRP will allow to initiate sooner the compressive treatment during the post
graft surgery evolution, in fewer days on average than the traditional method (18 ds).
2. The use of PRP will maintain the same initial size of the graft. The study's domain
corresponds to burn sequelae on children in treatment with reconstructive surgery due
to retractile sequelae located on their upper and lower limbs, with functional
compromise during their growth process.
One of the treatments used for this problem is the surgical technique of with release of
burn contractures and skin graft.
Split skin grafts are at risk of suboptimal "take" due to bleeding and infection which
would, on the one hand, delay the initiation of the rehabilitation with preventive
compression to avoid the retraction of the grafted area.
20% of the children that arrive in COANIQUEM (approximately 7,000 annually), require
rehabilitation. Of these, 32% have surgery and 9% of those are release of burn contractures
and skin graft mainly on extremities.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Treatment
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