Burns Clinical Trial
Official title:
Application of Cultured Autologous Keratinocytes in Combination With a Meshed Split Skin Autograft for Burn Wound Healing
In this study the treatment of full thickness burn wounds with cultured autologous keratinocytes in combination with meshed split skin autograft versus meshed split skin graft alone will be compared. It is expected that the application of cultured autologous keratinocytes in combination with a meshed split skin autograft will improve wound healing and scar formation.
The standard treatment for extensive burn wounds is transplantation with meshed split skin
graft. Disadvantages of this treatment are that healing of large full thickness burn wounds
is still accompanied by scar formation. Even standard treatment, transplantation with a
(meshed) split skin autograft, does not result in satisfactory functional and cosmetic
appearance of the healed wound. Due to limited available donor sites meshes needs to be
enlarged. Bigger enlargements of meshes give more scarring and mesh pattern are still visible
in scars, probably because wound closure still needs several weeks. Application of cultured
autologous keratinocytes may enhance wound closure and improve outcome of healing.
Primary objective: Does the application of cultured autologous keratinocytes on deep burn
wounds accelerate wound closure Secondary objectives: Does the application of cultured
autologous keratinocytes on deep burn wounds improve scar quality with respect to scar
elasticity, colour/pigmentation and/or smoothness after 3 and 12 months.
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