Burns Clinical Trial
Official title:
A Prospective Longitudinal Study of the Effect of Burn Size on Cytomegalovirus Reactivation and Correlates of T Cell Immune Function in Patients Sustaining Significant Burn Injury
The purpose of this study is to evaluate the effect of burn injury on the human immune
system with a focus on cytomegalovirus (CMV) reactivation and the immunologic correlates of
latent viral reactivation.
Subjects will be patients admitted to the North Carolina Jaycee Burn Center with burn
injury.
Blood samples will be collected over time and will be evaluated for CMV reactivation and
immune cell phenotype.
The purpose of this research study is to learn about infections and the immune system in
people who suffer from burn injuries. The immune system changes after burn injury and
infection is one of the most common complications. Cytomegalovirus (CMV) is a virus that
most people are exposed to early in life; once you are exposed it lays inactive in your body
forever. When the immune system is suppressed, this virus can reactivate. We would like to
measure how this virus makes copies of itself in the blood stream in people with a burn
injury and to look at cell markers of the immune system.
This study involves baseline and weekly blood draws for approximately 8 weeks. If blood
tests show CMV infection, further monitoring of blood work may be needed after eight weeks.
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Observational Model: Cohort, Time Perspective: Prospective
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