Insulin on Post Burn Hypermetabolism

Burns Clinical Trial

Official title: Effects of Insulin on Post Burn Hypermetabolism

Status Completed

Clinical Trial Summary

The purpose of this study is to examine the effects of insulin on helping burn patients recover faster from their burns.

Clinical Trial Description

Severe injuries produce profound hypermetabolic stress responses which cause severe loss of lean body mass and muscle wasting, immunologic compromise, slowed wound healing, and related bone loss, all which contribute to increased morbidity, mortality, and prolonged recovery from injury. The results of hypermetabolism persist for weeks to months depending on the severity of the insult. Massive burns can cause severe catabolism and are an excellent model to study the general effects of injury on protein metabolism. Severe burns are characterized by dramatic increases in energy utilization and alterations in the metabolism of carbohydrates, fat, and protein.

Insulin treatment improves net protein synthesis in the severely burned, principally through improved muscle protein synthesis. Although controversy exist as to whether insulin is effective as an anabolic hormone through increasing protein synthesis or decreasing protein breakdown, we believe that consideration of the methods and experimental protocols used in the various studies bear consideration when evaluating this topic. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Burns

• NCT number: NCT00137254
• Study type: Interventional
• Source: United States Army Institute of Surgical Research
• Status: Completed
• Phase: N/A
• Start date: December 2005
• Completion date: August 2008