Burn Clinical Trial
Official title:
A Quantitative Study of the Metabolic Alterations in Protein Synthesis Rate That Occur in Burn Patients Over the Time Course of Their Injury Using Positron Emission Tomography.
Our specific aim is to gain an understanding of protein synthesis rates in burn patients at various times during their injury and recovery by using PET scans. This will be compared with healthy volunteer controls. We hope this will help optimize nutrition and care regimens for future burn patients.
Status | Not yet recruiting |
Enrollment | 64 |
Est. completion date | January 2010 |
Est. primary completion date | January 2010 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 70 Years |
Eligibility |
Inclusion Criteria: FOR HEALTHY VOLUNTEERS Healthy males and females 18-70 years of age. Laboratory results within MGH-accepted normal range. Within 20% of the ideal weight for their height. Supine and standing blood pressure within the range of 110/60 to 150/90 mm Hg Heart rate within the range of 46-90 beats/minute after 5 minutes of rest. Subjects <40 years old with HCT >=24, age 40-60 with HCT >=27, age 60-70 with HCT >=30. FOR BURN SUBJECTS: Inclusion Criteria: Burn Injury of >=5 % TBSA from any cause. 18 -70 years of age Stable hemodynamic and cardiopulmonary states as judged by the attending surgeons in the burn unit. Patient who is capable of giving full informed consent. Exclusion Criteria: FOR HEALTHY SUBJECTS Clinical evidence of physical or mental disease. Clinically significant abnormality of the laboratory tests. Known drug or alcohol dependence. History of drug allergy Taking standard prescription drugs within two weeks or investigational drugs within four weeks prior to the PET scan Diabetes mellitus and other metabolic endocrine disorders Pregnant or lactating FOR BURN SUBJECTS: Pregnant or lactating females |
Observational Model: Case Control, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
United States | Massachusetts General Hospital | Boston | Massachusetts |
Lead Sponsor | Collaborator |
---|---|
Massachusetts General Hospital | National Institute of General Medical Sciences (NIGMS) |
United States,
Carter EA, Yu YM, Alpert NM, Bonab AA, Tompkins RG, Fischman AJ. Measurement of muscle protein synthesis by positron emission tomography with L-[methyl-11C]methionine: effects of transamination and transmethylation. J Trauma. 1999 Aug;47(2):341-5. — View Citation
Fischman AJ, Hsu H, Carter EA, Yu YM, Tompkins RG, Guerrero JL, Young VR, Alpert NM. Regional measurement of canine skeletal muscle blood flow by positron emission tomography with H2(15)O. J Appl Physiol (1985). 2002 Apr;92(4):1709-16. — View Citation
Fischman AJ, Yu YM, Livni E, Babich JW, Young VR, Alpert NM, Tompkins RG. Muscle protein synthesis by positron-emission tomography with L-[methyl-11C]methionine in adult humans. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):12793-8. — View Citation
Hsu H, Yu YM, Babich JW, Burke JF, Livni E, Tompkins RG, Young VR, Alpert NM, Fischman AJ. Measurement of muscle protein synthesis by positron emission tomography with L-[methyl-11C]methionine. Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):1841-6. — View Citation
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