Clinical Trials Logo
  1. Home
  2. Burn Injury
  3. NCT00588796

Study of Fibrinogen Metabolism During Severe Trauma and Burns

Burn Injury Clinical Trial

Official title:
Alteration in Fibrinogen Metabolism in Patients With Severe Burns and Traumatic Injuries

Clinical Trial Summary

To study the fibrinogen metabolic changes in relation to coagulation disorder in patients with severe burns and trauma injuries. As a result of the burn or trauma injury breakdown of fibrinogen is accelerated.

Clinical Trial Description

In this protocol, we will investigate fibrinogen metabolism in burn and trauma patients, using an 8h infusion of stable isotopes labeled amino acids (1-13C-phenylalanine, 2H5-phenylalanine, and 2H3-ketoisocaporate). The increase of the labeled amino acids incorporating into fibrinogen during the infusion and the decay of labeled fibrinogen after stopping the isotopes infusion (as measured by GC-MS) will be used to calculate fibrinogen synthesis and degradation. Stable isotopes are non-radioactive. ;

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00588796
Study type Observational
Source United States Army Institute of Surgical Research
Contact
Status Completed
Phase N/A
Start date February 2005
Completion date January 2014
View Details
See also
  Status Clinical Trial Phase
Completed NCT02210208 - A Soft Silicone Wound Contact Layer Containing Silver in the Treatment of Skin Grafts in Surgical Burn Patients. N/A
Withdrawn NCT02241941 - Evaluation of Single-dose Pharmacokinetics of Intravenous Daptomycin in Patients With Thermal Injury Phase 4
Completed NCT05063409 - Transfusion Ratio of Fresh Frozen Plasma (FFP) to Packed Red Blood Cell (PRBC) During Burn Excision and Grafting N/A
Completed NCT03730688 - Non-invasive Limb Compartment Pressure Measurement N/A
Recruiting NCT04368117 - STAT: Standard Therapy Plus Active Therapy N/A
Terminated NCT01773083 - Trial of Nebulized Heparin Versus Placebo for Inhalation Trauma Phase 3
Completed NCT02092701 - Effects of Cholecalciferol Supplementation on Bone Health and Muscle Strength in Adults During Post-burn Period N/A
Recruiting NCT06263296 - Smartphone Assisted Self-management Education for Adult Burn Patient at Aftercare N/A
Completed NCT02145130 - Phase I Study for Autologous Dermal Substitutes and Dermo-epidermal Skin Substitutes for Treatment of Skin Defects Phase 1
Completed NCT01618630 - Amino Acid Supplementation in Recovery From Severe Burns N/A
Recruiting NCT05876442 - Efficacy of EPSW Plus HILT on Carpal Tunnel Syndrome Post Burn Injury N/A
Completed NCT04417439 - The Effect of Acute Phase Treatment Approaches on Creatine Kinase and the Musculoskeletal System in Different Types of Burns
Completed NCT02417805 - Cutaneous Microcirculation After Remote Ischemic Preconditioning N/A
Completed NCT02417818 - Cutaneous Microcirculation After Plasma Therapy N/A
Completed NCT02417779 - Cutaneous Microcirculation After Extracorporeal Shock Wave Therapy N/A
Completed NCT01404026 - Effects of Transcranial Direct Current Stimulation (tDCS) on Neuropathic Symptoms Due to Burn Injury N/A
Completed NCT03204669 - Trace Element Repletion Following Severe Burn Injury N/A
Recruiting NCT04947449 - Potential Benefits of Laser Treatment on Skin Blood Flow and Sweating in Burn Survivors
Not yet recruiting NCT05532488 - Inulin in Burn-induced Insulin Resistance N/A
Recruiting NCT02189538 - Effect of n-3 PUFA From Fish in Enteral Nutrition of Major Burn Patients N/A