Impact of Neurological Diseases on the Prognosis of Bullous Pemphigoid: A Retrospective Study of 178 Patients

Bullous Pemphigoid Clinical Trial

Official title:

Impact of Neurological Diseases on the Prognosis of Bullous Pemphigoid: A Retrospective Study of 178 Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03320798
• Other study ID #: 2016Ao004
• Status: Completed
• Phase: N/A
• First received: October 23, 2017
• Last updated: October 23, 2017
• Start date: October 1, 2013
• Est. completion date: March 1, 2015

Study information

• Verified date: October 2017
• Source: CHU de Reims
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Bullous pemphigoid affects mainly elderly patients. It is often associated with neurologic disorders, which represent a major risk factor of the disease

Description:

The aim was to determine whether neurologic disorders, especially dementia, influences outcome and mortality of patients with bullous pemphigoid.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 178
• Est. completion date: March 1, 2015
• Est. primary completion date: October 1, 2014
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• patients presenting bullous pemphigoid using the following criteria: clinical features typical of BP with presence of at least three out of four well-established criteria of Vaillant et al., subepidermal blister on skin biopsy and deposits of IgG and/or C3 in a linear pattern along the epidermal basement membrane zone by direct IF

• patients consulting at dermatology department of Reims Teaching Hospital (France) between 1997 and 2011

Related Conditions & MeSH terms

• Bullous Pemphigoid
• Nervous System Diseases
• Pemphigoid, Bullous

Intervention

Other:
• Data record

Locations

Country	Name	City	State
France	Damien JOLLY	Reims

Sponsors (1)

Lead Sponsor	Collaborator
CHU de Reims

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	neurological disease	neurological disease are dementia (Alzheimers disease or other dementia), Parkinson's syndrome and stroke. Diagnosis of dementia was carried out in several ways: after examination by a neurologist or geriatrician, when the Mini Mental State was less than or equal to 17 or in the presence of a demonstrated and clinically evident dementia.	Day 0