Examining Common Substrates of Eating and Alcohol Use Disorders

Bulimia Nervosa Clinical Trial

Official title:

Examining Common Substrates of Eating and Alcohol Use Disorders

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01172210
• Other study ID #: #5973/6951R
• Status: Completed
• Phase: N/A
• First received: July 28, 2010
• Last updated: August 20, 2014
• Start date: July 2009
• Est. completion date: June 2014

Study information

• Verified date: April 2013
• Source: New York State Psychiatric Institute
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

A substantial percentage of individuals with bulimia nervosa (BN) also meet criteria for a co-occurring substance use disorder, such as alcohol abuse or dependence; however, research examining this sub-group of patients with BN is limited. Understanding characteristics common to both eating and alcohol use disorders may enhance understanding of the mechanisms that could contribute to the co-occurrence and perpetuation of these disorders. Individuals with BN and alcohol use disorders appear to share some behavioral traits, and therefore, the primary aim of the current study is to compare patients with BN with and without an alcohol use disorder and normal controls on measures assessing an individual's mood and ability to perform certain tasks. Participants will be asked to complete computer-administered and paper-and-pencil assessments and two laboratory test meals on separate days. By probing the underpinnings of BN and alcohol use disorders, the investigators can determine whether these disorders have a shared diathesis, which will lay an essential foundation for future research to examine biological and genetic correlates of these disorders. Finally, as little is known about the treatment of patients with BN and a co-occurring alcohol use disorder, an exploratory aim of the current study is evaluate the suitability and efficacy of a 20-session cognitive-behavioral treatment (CBT) addressing both bulimic symptoms and alcohol use.

Description:

A substantial percentage of individuals with bulimia nervosa (BN) also meet criteria for a co-occurring substance use disorder, such as alcohol abuse or dependence; however, research examining this sub-group of patients with BN is limited. Understanding characteristics common to both eating and alcohol use disorders may enhance our understanding of the mechanisms that could contribute to the co-occurrence and perpetuation of these disorders. The primary aim of the current study is to compare patients with BN with and without an alcohol use disorder and normal controls on computer-administered and paper-and-pencil assessments and in two laboratory test meals (a binge meal and a normal meal) on separate days. Participants will also complete self-report and interview measures of eating disorder symptoms and alcohol consumption. By probing the underpinnings of BN and alcohol use disorders, we can determine whether these disorders have a shared diathesis, which will lay an essential foundation for future research to examine biological and genetic correlates of these disorders. Finally, as little is known about the treatment of patients with BN and a co occurring alcohol use disorder, an exploratory aim of the current study is to evaluate the suitability and efficacy of a 20-session cognitive-behavioral treatment (CBT) addressing both bulimic symptoms and alcohol use.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 61
• Est. completion date: June 2014
• Est. primary completion date: June 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Age 18-45

• Diagnosis of bulimia nervosa with or without a co-occurring alcohol use disorder

• English speaking

• Weight above 80% of ideal

Exclusion Criteria:

• Other significant psychiatric conditions requiring treatment or a significant medical condition

• Pregnancy

• Current use of psychotropic medication

• History of neurological disorder (e.g., dementia, stroke seizure)

• Food allergy to items in the lunch buffet

• Positive urine drug screen

• Current or post eating disorder diagnosis or history of binge eating or vomiting

• Current or past alcohol or substance abuse or dependence

Study Design

N/A

Related Conditions & MeSH terms

• Alcohol Drinking
• Alcohol Use Disorders
• Bulimia
• Bulimia Nervosa

Locations

Country	Name	City	State
United States	New York State Psychiatric Institute	New York	New York

Sponsors (1)

Lead Sponsor	Collaborator
New York State Psychiatric Institute

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Eating Behavior		Baseline	No

External Links

•   Link