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NCT06457646 Clinical Trial

mRNA Expression and Genetic Polymorphisms Affecting DRD3 (rs6280) and HTR2A (rs6313) in Bruxism

Bruxism Clinical Trial

Official title:
mRNA Expression and Genetic Polymorphisms Affecting DRD3 (rs6280) and HTR2A (rs6313) in Bruxism

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT06457646
Other study ID # 011/2021
Secondary ID 0000-0002-5945-7
Status Not yet recruiting
Phase
First received
Last updated
Start date June 2, 2024
Est. completion date December 17, 2024

Study information
Verified date June 2024
Source University of Monastir
Contact Yosra Gassara
Phone 216-587-5455
Email chouchengassarayosra@gmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The goal of this observational study is to learn about the genetic factors influencing bruxism, a condition characterized by teeth grinding, in a group of participants. The main questions it aims to answer are: - Is there a significant association between the rs6313 polymorphism of the HTR2A gene and bruxism? - Is there a significant association between the rs6280 polymorphism of the DRD3 gene and bruxism? Participants will: Provide DNA samples for genotyping of the DRD3 (rs6280) and HTR2A (rs6313) polymorphisms. Provide RNA samples to assess changes in the expression of HTR2A and DRD3. Researchers will compare the genetic data and RNA expression levels between individuals with bruxism and those without (controls) to see if there are significant genetic differences and expression changes associated with bruxism.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 169
Est. completion date December 17, 2024
Est. primary completion date December 15, 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 60 Years
Eligibility Inclusion Criteria: - be above 18 years of age and have a confirmed diagnosis of bruxism Exclusion Criteria: - Systemic diseases, - orofacial dysfunction, - acute symptoms such as neurodegenerative diseases (specifically Parkinsons disease), - Taking medication such as anxiolytics

Study Design

Related Conditions & MeSH terms

Intervention

Genetic:
• Genetic polymorphism
The biological significance of HTR2A and DRD3 in bruxism remains unclear as molecular analyses, including genetic association studies, have not explored the mRNA expression of genes implicated in bruxism. This study aims to evaluate the influence of genetic polymorphisms affecting DRD3 (rs6280) and HTR2A (rs6313) on bruxism to identify potentially associated genotypes. Additionally, it aims to investigate the expression of HTR2A and DRD3 to elucidate their biological significance in bruxism.

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
University of Monastir

References & Publications (1)

Wieckiewicz M, Bogunia-Kubik K, Mazur G, Danel D, Smardz J, Wojakowska A, Poreba R, Dratwa M, Chaszczewska-Markowska M, Winocur E, Emodi-Perlman A, Martynowicz H. Genetic basis of sleep bruxism and sleep apnea-response to a medical puzzle. Sci Rep. 2020 M — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary PCR-RFLP Analysis 1 year
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