Brown Adipose Tissue Clinical Trial
Official title:
The Role of Vitamin A in Brown Fat Activity and Energy Metabolism
Vitamin A metabolites (retinoids) have shown to activate brown fat function in preclinical
studies, however the role of retinoids in human brown fat physiology and energy metabolism
remains elusive. This study aims to identify a possible association between retinoid
metabolism, brown fat activity, and energy expenditure in lean and obese subjects by using
FDG-PET-CT, PET-MR Scans and indirect calorimetry. Additionally we will analyze the genetic
profile of white and brown neck fat biopsies at room temperature and cold conditions in a
subset of the study participants. More detailed molecular studies (involving other potential
browning markers) will also be performed in adipocytes derived from human SVC.
The optimal duration of cold exposure will be determined in a pilot study. Therefore subjects
will be repeatedly exposed to cold and circulating retinoid levels and other plasma
parameters will be measured at various time points.
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