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NCT01797328 Clinical Trial

Does Cold Provocation Increase Brown Adipose Tissue Volume?

Brown Adipose Tissue, Human Clinical Trial

Official title:
Study of the Effects of Temperature on Amount of Brown Adipose Tissue in Humans

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01797328
Other study ID # Nystrom_koldstudie
Secondary ID Dnr2013/41-32
Status Completed
Phase N/A
First received February 18, 2013
Last updated April 24, 2017
Start date February 2013
Est. completion date June 2015

Study information
Verified date April 2017
Source University Hospital, Linkoeping
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

About 28 healthy subjects are randomized to 1 hour/day of coldprovocation or to the best of ability to avoid feeling cold, for 6 weeks. Basal metabolic rate and magnetic resonance (for determination of brown adipose tissue volume) imaging are performed before and after the study.

Recruitment information / eligibility
Status Completed
Enrollment 28
Est. completion date June 2015
Est. primary completion date May 2015
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 50 Years
Eligibility Inclusion Criteria: healthy subjects -

Exclusion Criteria: any significant disease, ot other conditions that interferes with magnetic resonance imaging

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• cold arm
1 hour/day of cold provocation of such an extent that it is unpleasant but does not cause shivering
• warm arm
To the best of ability avoid feeling cold during 6 weeks

Locations
Country Name City State
Sweden Faculty of Health Science, Linköping Linköping

Sponsors (1)
Lead Sponsor Collaborator
University Hospital, Linkoeping

Country where clinical trial is conducted

Sweden, 

Outcome
Type Measure Description Time frame Safety issue
Primary Brown Adipose Tissue, Absolute Volume Sub-clavicular brown adipose tissue volume by magnetic resonance imaging (liters) Baseline and 6 week