Stem Cells for Bronchopulmonary Dysplasia

Status Withdrawn

Clinical Trial Summary

Very preterm infants are at high risk to develop to bronchopulmonary dysplasia (BPD) for the lack of effective measures to prevent or ameliorate this common and serious disorder. BPD remains a major cause of mortality and lifelong morbidity in preterm infants

Clinical Trial Description

Several studies have shown that transplantation of mesenchymal stem cells (MSCs) in immunocompetent animals attenuates lung injury, such as impaired alveolarization, inflammatory response, increased apoptosis, and fibrosis. Human umbilical cord blood (hUCB) is considered a better source of MSCs because of their ready availability and greater proliferative capacity and less antigenicity than other cell types. transplantation of hUCB-derived MSCs should be effective in treating BPD. The safety and efficacy of MSC transplantation for prevention of BPD has not been tested previously, however. ;

Study Design

Related Conditions & MeSH terms

Bronchopulmonary Dysplasia

Clinical Trial Details

NCT number	NCT03378063
Study type	Interventional
Source	Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Contact
Status	Withdrawn
Phase	Early Phase 1
Start date	November 1, 2017
Completion date	December 30, 2022

View Details

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