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Genetic Susceptibility for Bronchopulmonary Dysplasia in Preterm Infants — GENBPD  

Bronchopulmonary Dysplasia Clinical Trial

Official title:
Polymorphisms of Genes Controlling Alveolar Development and Risk of Bronchopulmonary Dysplasia

Clinical Trial Summary

Despite considerable obstetric and neonatal advances in the care of very low birth weight (VLBW) neonates, bronchopulmonary dysplasia (BPD) continues to occur among 20 to 40% of surviving infants, and new ways for combatting this disease must be found. BPD appears to result from arrested lung development, but its etiology has not yet been fully established. Besides the role of the exposure of the immature lung to injurious factors in the development of BPD, a genetic susceptibility for BPD in preterm infants was recently evidenced. Taking advantage of new genomic technologies, the objective of the investigators' project is to identify predisposing human genetic variants through:

1. a genome-wide association (GWA) study in VLBW neonates,

2. a candidate-gene association study, including selection of single nucleotide polymorphisms (SNPs) found in (a) and

3. functional studies of any SNP found to be convincingly associated with BPD in (a) and (b).

Clinical Trial Description

n/a

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00904774
Study type Observational
Source Centre Hospitalier Intercommunal Creteil
Contact
Status Enrolling by invitation
Phase N/A
Start date May 2009
View Details
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