Bronchopulmonary Displasia Clinical Trial
Official title:
Investigation of Polymorphisms Defined in Specific Genes Which Are Associated With Bronchopulmonary Dysplasia In Turkish Population
Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects a ratio of up to
20-30% of infants prematurely born before 30rd week. Delay of starting to speak, cerebral
palsy and cognitive disorders may be seen in infants suffering from this disease. Although
all the evidence found on the specific mediators and pathways that regulate the mechanism by
studies made to understand the pathophysiologic mechanism, there hasn't been any remarkable
progress on preventing the development of BPD in new-born infants born below 1500gr body
weight. BPD is still one of the most important morbidity and mortality reasons in premature
infants. There is a need of further studies to understand the genetic background of BPD
specific to different populations, to identify polymorphisms related with the disease and for
developing genetic methods for early the diagnose of the disease.
With this purpose, first of all polymorphisms related with BPD and those which are related
with similar other lung diseases will be investigated. DNA samples derived from blood samples
of 200 patients (100 BPD infant and 100 control) will be examined for polymorphisms in
specific genes that are chosen in the light of the prior literature scanning. To the
investigators' knowledge, this will be the first study of a broad scanning of polymorphisms
related with BPD in Turkish population.
Bronchopulmonary dysplasia is a chronic lung disease that affects a ratio of up to 20-30% of
infants prematurely born before 30rd week. Delay of starting to speak, cerebral palsy and
cognitive disorders may be seen in infants suffering from this disease. Although all the
evidence found on the specific mediators and pathways that regulate the mechanism by studies
made to understand the pathophysiologic mechanism, there hasn't been any remarkable progress
on preventing the development of BPD in new-born infants born below 1500gr body weight. BPD
is still one of the most important morbidity and mortality reasons in premature infants.
There is a need of further studies to understand the genetic background of BPD specific to
different populations, to identify polymorphisms related with the disease and for developing
genetic methods for early the diagnose of the disease.
With this purpose, first of all polymorphisms related with BPD and those which are related
with similar other lung diseases will be investigated. DNA samples derived from blood samples
of 200 patients (100 BPD infant and 100 control) will be examined for polymorphisms in
specific genes that are chosen in the light of the prior literature scanning. To the
investigators' knowledge, this will be the first study of a broad scanning of polymorphisms
related with BPD in Turkish population.
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