Chronic Bronchitis Clinical Trial
Official title:
Comparison of Resistive Breathing Versus Inspiratory Hold Technique in Patients With Chronic Bronchitis
The aim of the study is to determine the importance and impact of resistive breathing techniques versus inspiratory hold techniques in patients with chronic bronchitis and specially to find out if there are any changes seen in results measured via the incentive spirometer.
Chronic Bronchitis (CB) is defined as a chronic cough and sputum production for at least 3 months a year for 2 consecutive years. It is covered under the umbrella term of Chronic Obstructive Pulmonary Disease (COPD). Chronic bronchitis is thought to be caused by overproduction and hypersecretion of mucus by goblet cells. Epithelial cells lining the airway response to toxic, infectious stimuli by releasing inflammatory mediators and e.g. pro-inflammatory cytokines. During an acute exacerbation of chronic bronchitis, the bronchial mucous membrane becomes hyperemic and edematous with diminished bronchial mucociliary function. This, in turn, leads to airflow impediment because of luminal obstruction to small airways. The airways become clogged by debris and this further increases the irritation. The characteristic cough of bronchitis is caused by the copious secretion of mucus in chronic bronchitis. Pseudostratified epithelium, highlighting the pseudostratified epithelial cells, goblets cells (shown in blue), then underlying connective tissue.(3) To determine the importance and impact of resistive breathing techniques versus inspiratory hold techniques in patients with chronic bronchitis and specially to find out if there are any changes seen in results measured via incentive spirometer. There are few studies done over it whereas purpose of this research work is to compare these techniques to get better results. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01420445 -
Safety/Tolerability and Efficacy of YHD001 in Patients With Acute and Chronic Bronchitis
|
Phase 2 | |
| Completed |
NCT01071161 -
The Effect of Azithromycin in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Chronic Productive Cough
|
Phase 3 | |
| Completed |
NCT00903955 -
Mucus Dehydration and Evolution of Chronic Obstructive Pulmonary Disease (COPD) Lung Disease
|
N/A | |
| Terminated |
NCT00524095 -
Bronchiectasis in Chronic Obstructive Pulmonary Disease (COPD) Patients: Role of Prophylaxis
|
Phase 2 | |
| Completed |
NCT00129883 -
Adherence to Guidelines for Antibiotic Use in Respiratory Infections at Hospitals
|
N/A | |
| Recruiting |
NCT05075057 -
Immunogenicity and Safety of an Inactivated COVID-19 Vaccine in Patients Aged ≥60 Years With Chronic Bronchitis and COPD
|
Phase 4 | |
| Recruiting |
NCT05075083 -
Immunogenicity and Safety of an Inactivated COVID-19 Vaccine in Elderly People With Chronic Bronchitis and COPD
|
Phase 4 | |
| Terminated |
NCT02838108 -
The Relationship Between GOLD Risk Group and Clinical Outcomes in a Community-based COPD Cohort
|
||
| Completed |
NCT02128529 -
Epidemiology of Chronic Bronchitis in Patients With Chronic Obstructive Pulmonary Disease (COPD)
|
N/A | |
| Withdrawn |
NCT00298402 -
Macrophages in Smokers' Lung
|
N/A | |
| Completed |
NCT00298389 -
Macrophage Phagocytosis in COPD
|
||
| Terminated |
NCT00132951 -
KEYS: Study Comparing Clinical Health Outcomes of Telithromycin Versus Azithromycin in Outpatients With Community-acquired Lower Respiratory Tract Infections
|
Phase 4 | |
| Active, not recruiting |
NCT01969344 -
Study of COPD Subgroups and Biomarkers
|
||
| Completed |
NCT00680056 -
Add-on Effects of Tiotropium Over Formoterol in Exercise Tolerance on Chronic Obstructive Pulmonary Disease Patients
|
Phase 4 | |
| Completed |
NCT00106080 -
Improving the Quality of End-of-Life Communication for Patients With Chronic Obstructive Pulmonary Disease (COPD)
|
N/A | |
| Completed |
NCT00042718 -
A Study of the Effectiveness and Safety of High Dose, Short-course Levofloxacin in the Treatment of Acute Bacterial Exacerbation (Worsening) of Chronic Bronchitis.
|
Phase 3 | |
| Completed |
NCT02099799 -
The Effect of Physical Activity Promotion on Short and Long-term Outcomes in COPD
|
N/A | |
| Completed |
NCT00342030 -
Dietary and Genetic Factors in Asthma & Chronic Bronchitis in a Cohort of Chinese Singaporeans
|
N/A | |
| Withdrawn |
NCT02341183 -
Novel Therapies for Muco-Obstructive Lung Diseases: Testing the Transnasal Pulmonary Delivery Device in COPD/CB Subjects
|
N/A | |
| Completed |
NCT00876577 -
VICTOR - Avelox® Intravenous (i.v.) in Acute Exacerbations of Chronic Bronchitis
|
N/A |