Bronchiolitis Clinical Trial
Official title:
Nebulized Hypertonic Saline in the Treatment of Bronchiolitis in Infants
Bronchiolitis is a common viral lung infection in infants. Standard treatment often includes the use of inhaled medications which are usually first mixed with a standard salt solution. Inhalation of a more concentrated salt solution (hypertonic saline) has been successfully used to treat other types of lung disease in children and adults. The purpose of this study is to see if using inhaled hypertonic saline helps infants with bronchiolitis get better more quickly.
Bronchiolitis is a common illness in infants and is associated with a significant morbidity.
Standard therapy is controversial and largely ineffective; care is mostly supportive
although nebulized medications continue to be commonly used. These medications are typically
mixed with normal saline to produce a sufficient volume for efficient nebulization.
Inhaled hypertonic saline has been used to aid airway clearance in children with cystic
fibrosis. It has also been used, in low dose, in two small studies in children with
bronchiolitis. The current study is a randomized, double-blind, placebo-controlled,
multi-center trial comparing frequent dosing with 3% hypertonic saline compared to normal
saline in the treatment of infants hospitalized with bronchiolitis.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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