Clinical Trials Logo
  1. Home
  2. Bronchiolitis, Viral
  3. NCT00122785

Single Injection of Dexamethasone for Acute Bronchiolitis in Young Children

Bronchiolitis, Viral Clinical Trial

Official title:
Efficacy of Single Injection of Dexamethasone for Acute Bronchiolitis in Children Younger Than 2 Years Old: A Randomized, Double-Blind, Placebo Controlled Trial

Clinical Trial Summary

The purpose of this study was to determine whether a single intramuscular injection of dexamethasone decreased the duration of symptoms of acute bronchiolitis in young children.

Clinical Trial Description

Acute bronchiolitis is an infection of the lower respiratory tract causing inflammation of the small airways, leading to bronchiolar obstruction. Corticosteroids are frequently prescribed as anti-inflammatory drugs. The usefulness of corticosteroids for this disease remains controversial, despite many randomized controlled trials (RCTs). Recently, a meta-analysis and systemic review showed significant improvement in clinical symptoms, length of hospital stay and duration of symptoms in children with this disease after treatment with various regimens of systemic corticosteroids.

Dexamethasone is a long acting corticosteroid with biologic half-life ranging from 36-72 hours. A single dose of dexamethasone has been the standard recommendation for the treatment of croup which has a similar pathophysiology without evidence of adverse effects. Furthermore, there is no previous report of this single dosage form of dexamethasone for the treatment of acute bronchiolitis in young children. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00122785
Study type Interventional
Source Khon Kaen University
Contact
Status Completed
Phase N/A
Start date April 2002
Completion date September 2004
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT04989114 - Nasal Bubble Continuous Positive Airway Pressure in Reducing Respiratory Distress in Children With Bronchiolitis N/A
Recruiting NCT04287959 - SWISH Trial (Strategies for Weaning Infants on Supportive High Flow) N/A
Not yet recruiting NCT01618175 - Home Oxygen Treatment of Childhood Acute Bronchiolitis N/A
Completed NCT01247064 - Hypertonic Saline for Acute Bronchiolitis Phase 4
Completed NCT03062917 - Nasal and Bronchial Absorption Sampling in RSV Bronchiolitis N/A
Recruiting NCT06030505 - Effectiveness of Nirsevimab in Children Hospitalised With RSV Bronchiolitis
Completed NCT02571517 - Glucocorticoid Therapy Impact on the Inflammatory Response and Clinical Evolution in Patients With Severe Bronchiolitis Phase 4
Completed NCT02853838 - Chest Physiotherapy in Infants Between 0 and 12 Months Old With Acute Bronchiolitis SRV(+) N/A
Terminated NCT03252119 - High Flow Oxygen Therapy vs Standard Care in Infants With Viral Bronchiolitis N/A
Active, not recruiting NCT04740294 - Efficacy of Magnesium Sulfate Bolus in Pediatric Patients With Bronchiolitis Phase 2/Phase 3
Terminated NCT03959384 - Efficacy and Safety of Curosurf® in Patients Invasively Ventilated for Severe Bronchiolitis Under 12 Months of Age Phase 3
Completed NCT00119002 - The Effectiveness of Oral Dexamethasone for Acute Bronchiolitis Phase 4
Terminated NCT04221087 - Steroid Use in Non-RSV Bronchiolitis Phase 4
Recruiting NCT04764929 - Pediatric Helmet CPAP Pilot Study N/A