Bronchiolitis Obliterans Clinical Trial
Official title:
Extracorporeal Photopheresis in Patients With Bronchiolitis Obliterans Syndrome (BOS) After Lung Transplantation
Investigation of photopheresis as new therapy regimen in patients with bronchiolitis obliterans syndrome after lung transplantation in a controlled, randomized study
Bronchiolitis obliterans syndrome is the major cause of mortality after lung
transplantation. 5 years after lung transplantation about 50% of all patients have this
syndrome. There are nearly none therapy options. Besides effective therapy of any
gastrooesophageal reflux and an oral medication with azithromycin none further regimens are
known. Photopheresis could show in several studies a benefit for patients with gvhd after
bone marrow transplantation or for chronic rejection after any other solid organ
transplantation. Just little case reports could show beneficial effect in patients with bos
after lung transplantation.
This is the first controlled, randomized study with patients with bos after lung
transplantation to investigate the effectiveness of this therapy in that patients.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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