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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05783869
Other study ID # 23455668
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date March 25, 2023
Est. completion date November 1, 2023

Study information

Verified date March 2023
Source Assiut University
Contact Shaadad Shaddad, MD
Phone +201111171930
Email shaddad_ahmad@yahoo.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Effect of cardiovascular comorbidities on disease severity and quality of life in Patients with acute exacerbation of non-cystic fibrosis bronchiectasis


Description:

The study will include patients with bronchiectasis, and in an attempt to correlate the effect and burden of cardiovascular comorbidities in those patients, we will study the quality of life in those patients in comparison to the control group ( patients with bronchiectasis and without any other comorbidities) using SF-36 quality of life questionnaire. We will also study the inflammatory markers in both groups using D-dimer, BNP, and CRP and correlate them with the frequency of hospital admission, the severity of symptoms, and the general health state.


Recruitment information / eligibility

Status Recruiting
Enrollment 30
Est. completion date November 1, 2023
Est. primary completion date September 1, 2023
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: • Any Patients with Bronchiectasis had no comorbidities other than cardiovascular comorbidities during the study period. Exclusion Criteria: - Any Patients who refuse to participate in the study. - Any other comorbidity or end-organ failure may affect the study's result.

Study Design


Related Conditions & MeSH terms


Intervention

Device:
Echocardiography
echocardiographic study of both groups

Locations

Country Name City State
Egypt Assiut unviresty - Faculty of Medicine Assiut

Sponsors (2)

Lead Sponsor Collaborator
Assiut University Aliae AR Mohamed Hussein [ahussein

Country where clinical trial is conducted

Egypt, 

Outcome

Type Measure Description Time frame Safety issue
Primary assessment of BNP (Brain natriuretic peptide) pg/ml levels in patients with bronchiectasis and cardiovascular comorbidities. Serum BNP (Brain natriuretic peptide) pg/ml will be compared in both groups. March 2023 to September 2023
Primary Assessment of Quality of life in patients and control groups using The Short Form (36) Health Survey (SF-36) The Short Form (36) Health Survey will be performed in both groups. The SF-36 consists of eight scaled scores, which are the weighted sums of the questions in their section. Each scale is directly transformed into a 0-100 scale on the assumption that each question carries equal weight. The lower the score the more disability. The higher the score the less disability i.e., a score of zero is equivalent to maximum disability and a score of 100 is equivalent to no disability. March 2023 to September 2023
Secondary Hospitalization frequency in patient group compared to control group. Number of hospital admission in the last year will be compared in both groups. March 2023 to September 2023
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