Bronchiectasis Clinical Trial
Official title:
Effectiveness of Procalcitonin-Guided Antibiotic Therapy in Acute Exacerbations of Bronchiectasis: a Randomized Controlled Trial
Verified date | February 2017 |
Source | Qilu Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
To explore effectiveness of procalcitonin-guided antibiotic therapy in acute exacerbations of bronchiectasis, and to explore the clinical value of procalcitonin in bronchiectasis.
Status | Completed |
Enrollment | 210 |
Est. completion date | February 1, 2017 |
Est. primary completion date | July 1, 2016 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years to 80 Years |
Eligibility |
Inclusion Criteria: 1. Bronchiectasis was diagnosed by high-resolution computed tomography based on the criteria published by McShane PJ et al. 2. Acute exacerbations of bronchiectasis. 3. Aged >= 18 years. 4. Procalcitonin been detected after admission. Exclusion Criteria: 1. Associated with chronic obstructive pulmonary disease. 2. Associated with asthma. 3. Traction bronchiectasis caused by pulmonary fibrosis. 4. Rule out other possible cause procalcitonin increased diseases such as cancer, connective tissue disease, active tuberculosis, chronic liver disease and respiratory system than the bacterial infection. 5. Clinical data were incomplete. 6. Can not follow up with the person. |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Qilu Hospital |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Antimicrobial prescription rate | 14 days | ||
Primary | Number of days of antimicrobial application | 14 days | ||
Primary | The number of days in hospital | 14 days | ||
Secondary | Effective rate of clinical treatment | 14 days | ||
Secondary | Quality of life score | 6 months | ||
Secondary | Adverse reaction rate | 14 days | ||
Secondary | Bacterial resistance rate | 14 days | ||
Secondary | The incidence of complications | 14 days | ||
Secondary | fungal infection rate | 14 days | ||
Secondary | mortality rate | 14 days | ||
Secondary | The proportion of patients with at least once acute exacerbation in 6 months | 6 months |
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