Bronchiectasis Clinical Trial
Official title:
A Randomized Controlled Trial of Long Term Airway Clearance With Oscillating Positive End Expiratory Pressure Device Versus Autogenic Drainage in People With Bronchiectasis
In this study, investigating two modes of chest physiotherapy on lung clearance index (LCI), 50 patients with bronchiectasis will be randomized to either oPEP or autogenic drainage.
One of the fundamental treatments in the management of bronchiectasis is airway clearance,
which effectively rids the airways of mucus to prevent secondary infection and inflammation.
While effective airway clearance is widely accepted as a first line treatment, the choice of
airway clearance method is complicated by lacking evidence base. One of the obstacles to
establishing evidence of efficacy of an airway clearance technique or device is the
limitations in the choice of endpoints.
Aerobika (Trudell medical international, Canada) is an oscillating positive expiratory
pressure (oPEP) device, designed and developed for the effective clearance of secretions in
people with suppurative lung diseases. It has been tested and found safe and effective in
chronic obstructive pulmonary disease (COPD) - chronic bronchitis.
The lung clearance index (LCI) measured by multiple breath washout (MBW) is a measure of
ventilation inhomogeneity and has been shown to be a sensitive lung function test in early
lung disease. Its usefulness has been demonstrated in cystic fibrosis (CF), particularly in
children and adults with mild disease. LCI has been assessed in bronchiectasis and has been
found to be significantly different from normal subjects, and to correlate with Forced
Expiratory Volume in 1 second (FEV1).
The aim of this study is to test the long term effect of daily lung clearance on LCI, quality
of life and exacerbations using the Aerobika oPEP device versus autogenic drainage (AD) in
people with bronchiectasis.
50 patients with confirmed bronchiectasis will be enrolled in this study. Participants will
be randomized to daily physiotherapy with either Aerobika or Autogenic drainage. Change in
LCI, measured before and after one month, will be the primary endpoint of this study.
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