Bronchiectasis Clinical Trial
Official title:
Efficacy of Azithromycin in Treatment of Bronchiectasis
Bronchiectasis is a chronic lung condition characterised primarily by dilatation of the airways. Only a small number of clinical studies have been conducted investigating the use of macrolides to treat non-cystic fibrosis bronchiectasis. The purpose of this study is to determine the efficacy of 12 weeks treatment with azithromycin in adult patients with non-cystic fibrosis bronchiectasis.
Previous studies of various macrolides with small sample sizes have reported some benefit
with the reduction of sputum volume in bronchiectasis patients. However, macrolide therapy
could not yet be confidently used to treat bronchiectasis, given the diffuse nature of these
findings. These studies have had a wide range of hypotheses, and have not necessarily
focused on the anti-inflammatory effects of macrolides. Furthermore, these studies are few
in number, and not all have been placebo-controlled or double-blinded. This, combined with
the small sample sizes used, limits the reliability of these results. This study aims to
expand on these limited published findings by investigating a larger sample population with
different endpoints. Sputum volume and quality of life have been selected as important
variables to aid in assessing efficacy.
This study aims to be independent of previous studies in a number of ways. This is the only
study of bronchiectasis patients to formally investigate quality of life after treatment
with a macrolide, and the potential carryover effect of azithromycin therapy. This study
will also expand on the findings of previous studies of macrolides in bronchiectasis by
incorporating a larger sample size into the trial.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05034900 -
Does Addition of Oscillatory Positive Expiratory Pressure (OPEP) Device to a Chest Physiotherapy Program Provide Further Health Benefits in Children With Bronchiectasis?
|
N/A | |
Recruiting |
NCT04101448 -
Prevalence of Bronchiectasis in COPD Patients
|
||
Withdrawn |
NCT03376204 -
Pain Mechanisms in Patients With Bronchiectasis
|
||
Completed |
NCT02550821 -
Comparison of Physical Activity Level Between Patients With Bronchiectasis and Healthy Subjects
|
||
Completed |
NCT02656992 -
Effects of High Intensity Inspiratory Muscle Training on Exercise Capacity in Patients With Bronchiectasis
|
N/A | |
Completed |
NCT02282202 -
Evaluation of Oscillatory Positive Expiratory Pressure (oPEP) in Bronchiectasis and COPD
|
N/A | |
Completed |
NCT02048397 -
Pulmonary Rehabilitation Program (PRP) Versus PRP Plus Nutritional Supplementation in Patients With Bronchiectasis
|
N/A | |
Completed |
NCT01615484 -
Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability
|
N/A | |
Recruiting |
NCT01761214 -
Bacteriology and Inflammation in Bronchiectasis
|
N/A | |
Recruiting |
NCT02527486 -
Seoul National University Airway Registry
|
N/A | |
Completed |
NCT01578681 -
ELTGOL and Bronchiectasis. Respiratory Therapy
|
N/A | |
Completed |
NCT01854788 -
3 Airway Clearance Techniques in Non Cystic Fibrosis Bronchiectasis
|
N/A | |
Completed |
NCT00769119 -
A Phase II , Placebo-controlled Study to Assess Efficacy of 28 Day Oral AZD9668 in Patients With Bronchiectasis
|
Phase 2 | |
Completed |
NCT01117493 -
Expert Patient Self-management Programme Versus Usual Care in Bronchiectasis
|
N/A | |
Terminated |
NCT00524095 -
Bronchiectasis in Chronic Obstructive Pulmonary Disease (COPD) Patients: Role of Prophylaxis
|
Phase 2 | |
Recruiting |
NCT00129350 -
Assessment of Heart and Heart-Lung Transplant Patient Outcomes Following Pulmonary Rehabilitation
|
Phase 1 | |
Completed |
NCT00656721 -
Respiratory Mechanics Effects of Flutter Valve in Bronchiectasis Patients
|
N/A | |
Completed |
NCT04081740 -
Biological Determinants of Sputum Rheology in Chronic Airway Diseases
|
||
Enrolling by invitation |
NCT02546297 -
Comparisons of Inhaled LAMA or LAMA+LABA or ICS+LABA for COPD With Bronchiectasis
|
Phase 4 | |
Completed |
NCT03628456 -
Effect of HFCWO Vests on Spirometry Measurements
|
N/A |