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Intravenous (IV) Nitroglycerin for Versions in Multiparous Women — INVERT (02)  

Breech Presentation Clinical Trial

Official title:
Intravenous (IV) Nitroglycerin for Versions in Multiparous Women

Clinical Trial Summary

Breech presentations (where a baby presents with feet or bottom down) have an increased risk of perinatal and neonatal complications, and are usually delivered by cesarean section. As an alternative, so that the baby can be delivered vaginally, an attempt can be made to turn the baby so that it is head down: this manoeuvre is called an external cephalic version (ECV).

Drugs that relax the uterus (tocolytic agents) are sometimes used to help improve ECV success rates. Nitroglycerin is a tocolytic agent, but intravenous nitroglycerin has not been tested as an agent to help ECV. There is some suggestion that nitroglycerin may be more helpful in women who have not previously been pregnant (nulliparous women) than in women who have been pregnant more than once (multiparous women), and so we have planned two trials.

This study is designed to answer the following questions for multiparous women:

Will administration of IV nitroglycerin for uterine relaxation improve ECV success rates? Will an increase in ECV success result in a decreased cesarean section rate?

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00901758
Study type Interventional
Source University of Calgary
Contact
Status Completed
Phase N/A
Start date March 2003
Completion date February 2008
View Details
See also
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Terminated NCT00465712 - Effect of Amnioinfusion on External Cephalic Version Successful Rate N/A
Recruiting NCT03827226 - Breech External Cephalic Version Intervention Trial
Completed NCT00813683 - Cephalic Version by Acupuncture for Breech Presentation N/A
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Completed NCT00141687 - Early External Cephalic Version (ECV) 2 Trial N/A