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Prospective Research of Outcomes After Salpingo-oophorectomy — PROSper  

BRCA1 Gene Mutation Clinical Trial

Official title:
Prospective Research of Outcomes After Salpingo-oophorectomy

Clinical Trial Summary

PROSper is a prospective cohort study of 100 women 35-50 years of age with BRCA 1/2 mutations who have elected to either undergo risk reducing salpingo-oophorectomy (RRSO) or nonsurgical management. The investigators will compare the change in cardiovascular health, bone health, sexual function, quality of life, and menopausal symptoms over 3 years of follow-up between women who undergo RRSO (baseline just prior to surgery) and age-matched controls that do not undergo RRSO. The investigators hypothesis is that women who undergo a premature surgical menopause induced by RRSO have worse cardiovascular health and bone health compared with women who do not undergo RRSO.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01948609
Study type Observational
Source University of California, San Francisco
Contact
Status Completed
Phase
Start date July 2014
Completion date December 2021
View Details
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