Evaluation of Corrected Carotid Artery Flow Time as a Predictor of Fluid Responsiveness in Spontaneous Breathing Patients

Brain Tumor Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02843477
• Other study ID #: 4-2016-0426
• Status: Completed
• Start date: August 9, 2016
• Est. completion date: February 28, 2017

Study information

• Verified date: July 2018
• Source: Yonsei University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

It is still challenging to assess intravascular volume status in spontaneously breathing patients. Recently, the measurement of corrected flow time in carotid artery was introduced as quite useful, simple and noninvasive for the evaluation of circulating blood volume change. The aim of this study is to evaluate whether corrected carotid artery flow time as determined by ultrasonography can be a predictor of fluid responsiveness in spontaneously breathing patients before induction of general anesthesia.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 54
• Est. completion date: February 28, 2017
• Est. primary completion date: February 28, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 19 Years to 80 Years

Eligibility

Inclusion Criteria:

• adult patients (19-80 years of age) who were scheduled to undergo elective neurosurgery for brain tumor

Exclusion Criteria:

• BMI > 35 or < 15 kg/m2

• the presence of carotid artery stenosis > 50%

• systolic blood pressure > 160 mmHg

• cardiac rhythm other than sinus

• intracardiac shunt 6. valvular heart disease

• a left ventricular ejection fraction of < 50%

• right ventricular dysfunction 9

• chronic obstructive pulmonary disease

• pulmonary hypertension

• chronic kidney disease (eGFR < 60 mL/min/1.73m2)

• pregnancy

Related Conditions & MeSH terms

• Brain Tumor

Intervention

Device:
• ultrasonographic measurement of corrected flow time in carotid artery
Corrected carotid artery flow time is measured using 10-5 MHz linear probe on a portable ultrasound machine. On the two-dimensional image, the optimal image of the long-axis view is obtained at the left common carotid artery. The sample volume is placed on the center of the lumen, 2 cm proximal to the bulb, and a pulsed wave Doppler examination was performed while the Doppler beams were adjusted to ensure < 60° of angle for the best signal. Then, cardiac cycle time and carotid flow time is measured. Carotid flow time is measured between the upstroke of the flow tracing and the dicrotic notch, and it is corrected for pulse rate by dividing flow time by the square root of the cardiac cycle time to calculate corrected carotid artery flow time (flow time/vcycle time).

Locations

Country	Name	City	State
Korea, Republic of	Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Yonsei University

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	ultrasonographic measurement of corrected flow time in carotid artery	The ultrasonographic measurement of corrected flow time in carotid artery will be performed before fluid loading.	right before fluid loading
Primary	ultrasonographic measurement of corrected flow time in carotid artery	The ultrasonographic measurement of corrected flow time in carotid artery will be performed 5 minutes after fluid loading.	5 minutes after fluid loading