Brain Tumor Clinical Trial
Official title:
Cerebral Autoregulation and Carbon Dioxide Reactivity in Patients With Posterior Fossa Tumor
The normal cerebral blood flow is guided by factors such as cerebral autoregulation (CA) and
carbon dioxide reactivity (CO2R). Authors have demonstrated that CA and CO2R may be impaired
in presence of intracranial tumors.Most studies pertaining to assessment of CA and CO2R in
patients with brain tumors is limited to supratentorial tumors. Due to their anatomic
location, posterior fossa tumors result in obstruction of ventricular outflow, produce
hydrocephalus and features of raise intracranial pressure (ICP). It is possible that lesions
in the posterior fossa may affect CA and CO2R. It should also be noted that posterior fossa
surgeries are carried out in positions such as prone, lateral and sitting. Altered surgical
positions themselves affect systemic hemodynamics which may influence cerebral blood flow;
with presence of anesthetics further compromising the blood flow to the brain. Understanding
the homeostatic mechanisms of CA and CO2R may help in deciding proper positioning of
patients and maintenance of intraoperative hemodynamic.
The aim of this observational study was to evaluate CA and CO2R in patients with posterior
fossa tumor prior to surgical decompression of the lesion.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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