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Study of Intraoperative Radiotherapy for Patients With Large Brain Metastases Treated With Neurosurgical Resection

Brain Metastases Clinical Trial

Official title:
A Phase I/II Study of Intraoperative Radiotherapy for Patients With Large Brain Metastases Treated With Neurosurgical Resection

Clinical Trial Summary

The primary purpose of this study is to establish a maximum tolerated dose (MTD) through a dose-escalation trial using intraoperative radiotherapy (IORT) following neurosurgical resection for large brain metastases, and to determine the progression-free survival rate as in the recurrence rate of treated brain metastasis.

Clinical Trial Description

The potential for delivering ablative doses of radiation to the tumor bed while simultaneously sparing normal brain parenchyma from significant doses of radiation and reducing the potential for tumor repopulation has led to interest in the use of intraoperative radiotherapy (IORT) for brain metastasis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04040400
Study type Interventional
Source University of Louisville
Contact
Status Terminated
Phase N/A
Start date October 23, 2019
Completion date November 19, 2021
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