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Brain Insulin-sensitivity clinical trials

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NCT ID: NCT04700241 Completed - Vascular Function Clinical Trials

Nitrate and Brain Insulin-Sensitivity

NO-BRAINS
Start date: January 21, 2021
Phase: N/A
Study type: Interventional

Disturbances in brain insulin-sensitivity are not only observed in abdominal obesity and type 2 diabetes mellitus (T2D), but also during brain aging and in dementia. Inorganic nitrate may improve brain insulin-sensitivity, which can be quantified by measuring the gray-matter cerebral blood flow (CBF) response to intranasally administered insulin, through beneficial effects on brain vascular function. Therefore, we now hypothesize that inorganic nitrate, which can be found in several vegetables such as beetroot, improves brain insulin-sensitivity, as assessed by the gray-matter CBF response to intranasally administered insulin, in abdominally obese men.