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Brain Injury Traumatic Severe clinical trials

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NCT ID: NCT05778110 Recruiting - Clinical trials for Brain Injury Traumatic Severe

Multiomic Analysis of Traumatic Brain Injury and Hypertension Intracranial Hemorrhage Lesion Tissue

MOSS-THINK
Start date: April 1, 2023
Phase:
Study type: Observational

The goal of this experimental observation study is to figure out differently expressed biomarkers in lesion tissues in traumatic brain injury or hypertension intracranial hemorrhage patients. The main questions it aims to answer is: - Which RNA, protein and metabolites are differently expressed in lesion tissues? - What molecular mechanism is participated in TBI or ICH? Participants will be treated by emergency operation, and their lesion tissues will be collected during the operation.

NCT ID: NCT05048966 Recruiting - Dementia Clinical Trials

Comparison of Two Group Wellness Interventions for Individuals With Neurologic Conditions and Their Support Persons

Start date: December 8, 2022
Phase: N/A
Study type: Interventional

Approximately 5.3 million people live with a long-term disability resulting from a traumatic brain injury (TBI) and between 5-8% of those older than 60 suffer from Alzheimer's disease or other forms of dementia (ADRD). Consequences of these conditions can result in dramatic and persistent changes in functioning, impacting not only the patients, but also loved ones who become informal support persons. Many existing services help the family in the moment, but do not address long-term wellness. Thus, the purpose of this research study is to compare the effect of two different types of group wellness treatments for individuals with chronic mild TBI, moderate to severe TBI, and ADRD and their support persons.

NCT ID: NCT05038930 Recruiting - Clinical trials for Subarachnoid Hemorrhage

Mobilising Patients With Severe Brain Injury in Intensive Care

MAWERIC
Start date: October 1, 2021
Phase: N/A
Study type: Interventional

Introduction Patients with severe brain injury are often restricted to bed rest during the early period of brain injury which may lead to unwanted secondary complications. There is lack of evidence of when to initiate the first mobilisation. The Sara Combilizer® is an easy and efficient tool for mobilising patients with severe injuries, including brain injury. Through a randomised cross-over trial the investigators will investigate the impact of early mobilisation on patients with severe acquired brain injury caused by traumatic brain injury, subarachnoid brain injury or intracranial haematoma. The investigators hypothesise that mobilisation using the Sara Combilizer® does not affect partial oxygenation of brain tissue.

NCT ID: NCT04945213 Recruiting - Clinical trials for Brain Injury Traumatic Severe

Biperiden Trial for Epilepsy Prevention

BIPERIDEN
Start date: January 10, 2023
Phase: Phase 3
Study type: Interventional

One of the most important neurological consequences following Traumatic Brain Injury (TBI) is the development of post traumatic epilepsy (PTE). Nevertheless, there is still no effective therapeutic intervention to reduce the occurrence of PTE. In previous studies with animals models of epilepsy, the biperiden decreased the incidence and intensity of spontaneous epileptic seizures besides delaying their appearance. The aim of this study is the evaluation of biperiden as antiepileptogenic drug to prevent PTE and also the determination of side effects, evaluating its cost-effectiveness in patients with moderate and severe TBI.

NCT ID: NCT04331392 Recruiting - Clinical trials for Brain Injuries, Traumatic

Online Memory Intervention for Individuals With Traumatic Brain Injury

Start date: October 30, 2018
Phase: N/A
Study type: Interventional

This study will examine the behavioural and neurophysiological efficacy and feasibility of an online spatial navigation intervention for improving memory and brain health in individuals who have sustained moderate-severe traumatic brain injury.