Brain Injuries — Noninvasive Brain Stimulation Training
Citation(s)
Antal A, Brepohl N, Poreisz C, Boros K, Csifcsak G, Paulus W Transcranial direct current stimulation over somatosensory cortex decreases experimentally induced acute pain perception. Clin J Pain. 2008 Jan;24(1):56-63. doi: 10.1097/AJP.0b013e318157233b.
Boggio PS, Zaghi S, Lopes M, Fregni F Modulatory effects of anodal transcranial direct current stimulation on perception and pain thresholds in healthy volunteers. Eur J Neurol. 2008 Oct;15(10):1124-30. doi: 10.1111/j.1468-1331.2008.02270.x. Epub 2008 Aug 20.
Hamdy S, Rothwell JC Gut feelings about recovery after stroke: the organization and reorganization of human swallowing motor cortex. Trends Neurosci. 1998 Jul;21(7):278-82. Review.
Hummel F, Cohen LG Improvement of motor function with noninvasive cortical stimulation in a patient with chronic stroke. Neurorehabil Neural Repair. 2005 Mar;19(1):14-9.
Matsunaga K, Nitsche MA, Tsuji S, Rothwell JC Effect of transcranial DC sensorimotor cortex stimulation on somatosensory evoked potentials in humans. Clin Neurophysiol. 2004 Feb;115(2):456-60.
Pridmore S Substitution of rapid transcranial magnetic stimulation treatments for electroconvulsive therapy treatments in a course of electroconvulsive therapy. Depress Anxiety. 2000;12(3):118-23.
Que M, Schiene K, Witte OW, Zilles K Widespread up-regulation of N-methyl-D-aspartate receptors after focal photothrombotic lesion in rat brain. Neurosci Lett. 1999 Oct 1;273(2):77-80.
Ragert P, Franzkowiak S, Schwenkreis P, Tegenthoff M, Dinse HR Improvement of tactile perception and enhancement of cortical excitability through intermittent theta burst rTMS over human primary somatosensory cortex. Exp Brain Res. 2008 Jan;184(1):1-11. Epub 2007 Aug 7. Erratum in: Exp Brain Res. 2008 Jan;184(1):141.
Ragert P, Vandermeeren Y, Camus M, Cohen LG Improvement of spatial tactile acuity by transcranial direct current stimulation. Clin Neurophysiol. 2008 Apr;119(4):805-11. doi: 10.1016/j.clinph.2007.12.001. Epub 2008 Jan 18.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.